Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

Dorothea Greiner, Tiziana Bonaldi, Ragnhild Eskeland, Ernst Roemer, Axel Imhof

Research output: Contribution to journalArticle

Abstract

Histone methylation plays a key role in establishing and maintaining stable gene expression patterns during cellular differentiation and embryonic development. Here, we report the characterization of the fungal metabolite chaetocin as the first inhibitor of a lysine-specific histone methyltransferase. Chaetocin is specific for the methyltransferase SU(VAR)3-9 both in vitro and in vivo and may therefore be used to study heterochromatin-mediated gene repression.

Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalNature Chemical Biology
Volume1
Issue number3
DOIs
Publication statusPublished - Aug 2005

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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