Identification of blood leukotrienes in classical migraine

P. P. Gazzaniga, P. Ferroni, L. Lenti, D. Lombardi, C. Mina, F. M. Pulcinelli, P. A. Rizzo, G. M. Pontieri

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

In five patients affected by classical migraine a longitudinal study was performed, dealing with the in vitro parameters of platelet aggregation, during prodromal, attack, post-attack and interval phases. These patterns were compared with the analysis of blook leukotrienes, carried out by use of analytical reversed phase HPLC. Presence of leukotriene C4 (LTC4) during prodromal and attack phases, corresponded to a transient inhibition of epinephrine-induced aggregation. Recovery towards normal or increased values of platelet aggregation occurred during both post-attack and interval phases, which were accompanied by the presence in blood of 5-12 dihydroxyeicosatetraenoic acid (5-12 DHETE) and/or leukotriene B4 (LTB4) respectively, and by their subsequent metabolic breakdown products. Hypotheses on the role of leukotrienes in the pathogenesis of migraine are discussed.

Original languageEnglish
Title of host publicationHeadache
Pages211-215
Number of pages5
Volume27
Edition4
Publication statusPublished - 1987

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Migraine with Aura
Leukotrienes
Platelet Aggregation
Leukotriene C4
Leukotriene B4
Migraine Disorders
Epinephrine
Longitudinal Studies
High Pressure Liquid Chromatography
Acids
In Vitro Techniques

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Gazzaniga, P. P., Ferroni, P., Lenti, L., Lombardi, D., Mina, C., Pulcinelli, F. M., ... Pontieri, G. M. (1987). Identification of blood leukotrienes in classical migraine. In Headache (4 ed., Vol. 27, pp. 211-215)

Identification of blood leukotrienes in classical migraine. / Gazzaniga, P. P.; Ferroni, P.; Lenti, L.; Lombardi, D.; Mina, C.; Pulcinelli, F. M.; Rizzo, P. A.; Pontieri, G. M.

Headache. Vol. 27 4. ed. 1987. p. 211-215.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gazzaniga, PP, Ferroni, P, Lenti, L, Lombardi, D, Mina, C, Pulcinelli, FM, Rizzo, PA & Pontieri, GM 1987, Identification of blood leukotrienes in classical migraine. in Headache. 4 edn, vol. 27, pp. 211-215.
Gazzaniga PP, Ferroni P, Lenti L, Lombardi D, Mina C, Pulcinelli FM et al. Identification of blood leukotrienes in classical migraine. In Headache. 4 ed. Vol. 27. 1987. p. 211-215
Gazzaniga, P. P. ; Ferroni, P. ; Lenti, L. ; Lombardi, D. ; Mina, C. ; Pulcinelli, F. M. ; Rizzo, P. A. ; Pontieri, G. M. / Identification of blood leukotrienes in classical migraine. Headache. Vol. 27 4. ed. 1987. pp. 211-215
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