In five patients affected by classical migraine a longitudinal study was performed, dealing with the in vitro parameters of platelet aggregation, during prodromal, attack, post-attack and interval phases. These patterns were compared with the analysis of blook leukotrienes, carried out by use of analytical reversed phase HPLC. Presence of leukotriene C4 (LTC4) during prodromal and attack phases, corresponded to a transient inhibition of epinephrine-induced aggregation. Recovery towards normal or increased values of platelet aggregation occurred during both post-attack and interval phases, which were accompanied by the presence in blood of 5-12 dihydroxyeicosatetraenoic acid (5-12 DHETE) and/or leukotriene B4 (LTB4) respectively, and by their subsequent metabolic breakdown products. Hypotheses on the role of leukotrienes in the pathogenesis of migraine are discussed.
|Title of host publication||Headache|
|Number of pages||5|
|Publication status||Published - 1987|
ASJC Scopus subject areas
- Clinical Neurology