Identification of categories at risk for high quality of life impairment in patients with vitiligo

F. Sampogna, D. Raskovic, L. Guerra, C. Pedicelli, S. Tabolli, L. Leoni, L. Alessandroni, D. Abeni

Research output: Contribution to journalArticlepeer-review


Background: Quality of life (QoL) in patients with vitiligo is strongly impaired. Therefore, it seems inadequate to describe the severity of the disease using only physical indicators. Objectives: To investigate the QoL of patients with vitiligo, identifying categories at risk for high impairment, also analysing single questions from a QoL instrument. Methods: The Skindex-29 questionnaire, a QoL dermatology-specific instrument, was completed by 181 consecutive patients with vitiligo. Answers to the Skindex-29 items were given on a five-point scale, from 'never' to 'all the time'. Results: The QoL problems more frequently experienced 'often' or 'all the time' were: worry of the disease getting worse (60%), anger (37%), embarrassment (34%), depression (31%), having social life affected (28%), and shame (28%). The prevalence of patients with probable depression or anxiety, evaluated using the 12-item General Health Questionnaire, was 39%, and the prevalence of patients with alexithymia, evaluated using the 20-item Toronto Alexithymia Scale, was 24%. The association of QoL impairment with psychological problems was very strong for all the items, and remained significant also when taking into account simultaneously gender, age, clinical severity, family history, and localization of vitiligo. Conclusions: Detailed information on QoL in patients with vitiligo may lead dermatologists to pay particular attention to patient categories at risk for a high QoL impairment.

Original languageEnglish
Pages (from-to)351-359
Number of pages9
JournalBritish Journal of Dermatology
Issue number2
Publication statusPublished - Aug 2008


  • Psychology
  • Quality of life
  • Questionnaire
  • Vitiligo

ASJC Scopus subject areas

  • Dermatology


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