identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1

Ewa A. Jankowska; Gerasimos S. Filippatos; Stephan von Haehling; Jana Papassotiriou; Nils G. Morgenthaler; Mariantonietta Cicoira; Joerg C. Schefold; Piotr Rozentryt; Beata Ponikowska; Wolfram Doehner; Waldemar Banasiak; Oliver Hartmann; Joachim Struck; Andreas Bergmann; Stefan D. Anker; Piotr Ponikowski

doi:10.1371/journal.pone.0014506

identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1

Ewa A. Jankowska, Gerasimos S. Filippatos, Stephan von Haehling, Jana Papassotiriou, Nils G. Morgenthaler, Mariantonietta Cicoira, Joerg C. Schefold, Piotr Rozentryt, Beata Ponikowska, Wolfram Doehner, Waldemar Banasiak, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Stefan D. Anker, Piotr Ponikowski

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article

Abstract

Objectives: We hypothesised that assessment of plasma C-terminal pro-endothelin-1 (CT-proET-1), a stable endothelin-1 precursor fragment, is of prognostic value in patients with chronic heart failure (CHF), beyond other prognosticators, including N-terminal pro-B-type natriuretic peptide (NT-proBNP). Methods: We examined 491 patients with systolic CHF (age: 63±11 years, 91%men, New York Heart Association [NYHA] class [I/ II/III/IV]: 9%/45%/38%/8%, 69% ischemic etiology). Plasma CT-proET-1 was detected using a chemiluminescence immunoassay. Results: Increasing CT-proET-1 was a predictor of increased cardiovascular mortality at 12-months of follow-up (standardized hazard ratio 1.42, 95% confidence interval [CI] 1.04-1.95, p = 0.03) after adjusting for NT-proBNP, left ventricular ejection fraction (LVEF), age, creatinine, NYHA class. In receiver operating characteristic curve analysis, areas under curve for 12-month follow-up were similar for CT-proET-1 and NT-proBNP (p = 0.40). Both NT-proBNP and CT-proET-1 added prognostic value to a base model that included LVEF, age, creatinine, and NYHA class. Adding CT-proET-1 to the base model had stronger prognostic power (p

Original language	English
Article number	e14506
Journal	PLoS One
Volume	6
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0014506
Publication status	Published - 2011

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Jankowska, E. A., Filippatos, G. S., von Haehling, S., Papassotiriou, J., Morgenthaler, N. G., Cicoira, M., Schefold, J. C., Rozentryt, P., Ponikowska, B., Doehner, W., Banasiak, W., Hartmann, O., Struck, J., Bergmann, A., Anker, S. D., & Ponikowski, P. (2011). identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1. PLoS One, 6(1), [e14506]. https://doi.org/10.1371/journal.pone.0014506

identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1. / Jankowska, Ewa A.; Filippatos, Gerasimos S.; von Haehling, Stephan; Papassotiriou, Jana; Morgenthaler, Nils G.; Cicoira, Mariantonietta; Schefold, Joerg C.; Rozentryt, Piotr; Ponikowska, Beata; Doehner, Wolfram; Banasiak, Waldemar; Hartmann, Oliver; Struck, Joachim; Bergmann, Andreas; Anker, Stefan D.; Ponikowski, Piotr.

In: PLoS One, Vol. 6, No. 1, e14506, 2011.

Research output: Contribution to journal › Article

Jankowska, EA, Filippatos, GS, von Haehling, S, Papassotiriou, J, Morgenthaler, NG, Cicoira, M, Schefold, JC, Rozentryt, P, Ponikowska, B, Doehner, W, Banasiak, W, Hartmann, O, Struck, J, Bergmann, A, Anker, SD & Ponikowski, P 2011, 'identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1', PLoS One, vol. 6, no. 1, e14506. https://doi.org/10.1371/journal.pone.0014506

Jankowska, Ewa A. ; Filippatos, Gerasimos S. ; von Haehling, Stephan ; Papassotiriou, Jana ; Morgenthaler, Nils G. ; Cicoira, Mariantonietta ; Schefold, Joerg C. ; Rozentryt, Piotr ; Ponikowska, Beata ; Doehner, Wolfram ; Banasiak, Waldemar ; Hartmann, Oliver ; Struck, Joachim ; Bergmann, Andreas ; Anker, Stefan D. ; Ponikowski, Piotr. / identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1. In: PLoS One. 2011 ; Vol. 6, No. 1.

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abstract = "Objectives: We hypothesised that assessment of plasma C-terminal pro-endothelin-1 (CT-proET-1), a stable endothelin-1 precursor fragment, is of prognostic value in patients with chronic heart failure (CHF), beyond other prognosticators, including N-terminal pro-B-type natriuretic peptide (NT-proBNP). Methods: We examined 491 patients with systolic CHF (age: 63±11 years, 91%men, New York Heart Association [NYHA] class [I/ II/III/IV]: 9%/45%/38%/8%, 69% ischemic etiology). Plasma CT-proET-1 was detected using a chemiluminescence immunoassay. Results: Increasing CT-proET-1 was a predictor of increased cardiovascular mortality at 12-months of follow-up (standardized hazard ratio 1.42, 95% confidence interval [CI] 1.04-1.95, p = 0.03) after adjusting for NT-proBNP, left ventricular ejection fraction (LVEF), age, creatinine, NYHA class. In receiver operating characteristic curve analysis, areas under curve for 12-month follow-up were similar for CT-proET-1 and NT-proBNP (p = 0.40). Both NT-proBNP and CT-proET-1 added prognostic value to a base model that included LVEF, age, creatinine, and NYHA class. Adding CT-proET-1 to the base model had stronger prognostic power (p",

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AU - Jankowska, Ewa A.

AU - Filippatos, Gerasimos S.

AU - von Haehling, Stephan

AU - Papassotiriou, Jana

AU - Morgenthaler, Nils G.

AU - Cicoira, Mariantonietta

AU - Schefold, Joerg C.

AU - Rozentryt, Piotr

AU - Ponikowska, Beata

AU - Doehner, Wolfram

AU - Banasiak, Waldemar

AU - Hartmann, Oliver

AU - Struck, Joachim

AU - Bergmann, Andreas

AU - Anker, Stefan D.

AU - Ponikowski, Piotr

PY - 2011

Y1 - 2011

N2 - Objectives: We hypothesised that assessment of plasma C-terminal pro-endothelin-1 (CT-proET-1), a stable endothelin-1 precursor fragment, is of prognostic value in patients with chronic heart failure (CHF), beyond other prognosticators, including N-terminal pro-B-type natriuretic peptide (NT-proBNP). Methods: We examined 491 patients with systolic CHF (age: 63±11 years, 91%men, New York Heart Association [NYHA] class [I/ II/III/IV]: 9%/45%/38%/8%, 69% ischemic etiology). Plasma CT-proET-1 was detected using a chemiluminescence immunoassay. Results: Increasing CT-proET-1 was a predictor of increased cardiovascular mortality at 12-months of follow-up (standardized hazard ratio 1.42, 95% confidence interval [CI] 1.04-1.95, p = 0.03) after adjusting for NT-proBNP, left ventricular ejection fraction (LVEF), age, creatinine, NYHA class. In receiver operating characteristic curve analysis, areas under curve for 12-month follow-up were similar for CT-proET-1 and NT-proBNP (p = 0.40). Both NT-proBNP and CT-proET-1 added prognostic value to a base model that included LVEF, age, creatinine, and NYHA class. Adding CT-proET-1 to the base model had stronger prognostic power (p

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