Identification of clinical predictive factors of oxaliplatin-induced chronic peripheral neuropathy in colorectal cancer patients treated with adjuvant Folfox IV

Bruno Vincenzi, Anna Maria Frezza, Gaia Schiavon, Chiara Spoto, Raffaele Addeo, Vincenzo Catalano, Francesco Graziano, Daniele Santini, Giuseppe Tonini

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Oxaliplatin-induced neuropathy is a dose-related side effect which occurs in almost 40 % of patients treated with oxaliplatin. Aim of the present study was to identify reliable clinical factors predicting its development and duration. Methods: One hundred sixty-nine completely resected colorectal cancer patients treated with adjuvant Folfox IV regimen were retrospectively included. The following pre-treatment clinical parameters were collected: hypocalcaemia, hypomagnesaemia, hypoalbuminaemia, anaemia, diabetes, chronic renal failure (CRF), folate deficiency, vitamin B12 deficiency, number of cycles received and habit to alcohol consumption. Incidence, grade (NCI-CTCAE v.3) and duration of neuropathy were recorded. Results: Incidence of neuropathy was found to be higher in patients with pre-treatment anaemia (p = 0.001), hypoalbuminaemia (p = 0.01) and hypomagnesaemia (p = 0.001) as well in those with habit to alcohol consumption (p = 0.003). Neuropathy durations were conversely associated with age, being longer in younger patients (p = 0.03), and again with hypoalbuminaemia (p = 0.04) and hypomagnesaemia (p = 0.002). No correlation was found with gender, hypocalcaemia, diabetes and CRF. The correlation between vitamin B12 and folate levels and the development of neurotoxicity were not analysed because of the high number of missing data in the population. Conclusions: Age, anaemia, hypoalbuminaemia, hypomagnesaemia and alcohol consumption are reliable and easily assessable clinical factors predicting incidence and length of oxaliplatin-induced neuropathy.

Original languageEnglish
Pages (from-to)1313-1319
Number of pages7
JournalSupportive Care in Cancer
Volume21
Issue number5
DOIs
Publication statusPublished - May 2013

Keywords

  • Clinical predictive factors
  • Colorectal cancer
  • Neurotoxicity
  • Oxaliplatin-induced neuropathy

ASJC Scopus subject areas

  • Oncology

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