Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells

Kurtis E. Bachman, Jason Sager, Ian Cheong, Marco Catto, Alberto Bardelli, Ben Ho Park, Bert Vogelstein, Angelo Carotti, Kenneth W. Kinzler, Christoph Lengauer

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) is a heterocyclic amine and is a common byproduct of cooked meat and fish. Although most cells undergo apoptosis when exposed to this mutagen, subsets develop resistance. Rather than die, these resistant cells persist and accumulate mutations, thereby driving tumorigenesis of exposed organs within the gastrointestinal tract. By applying a high-throughput cell-based screen of 32,000 small molecules, we have identified a family of compounds that specifically inhibit the growth of PhIP-resistant cancer cells. These compounds may prove useful for the treatment or prevention of gastrointestinal tumors arising after exposure to PhIP and related carcinogens.

Original languageEnglish
Pages (from-to)1026-1030
Number of pages5
JournalMolecular Cancer Therapeutics
Volume4
Issue number6
DOIs
Publication statusPublished - Jun 2005

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Growth
Carcinogens
Neoplasms
Mutagens
Meat
Amines
Gastrointestinal Tract
Carcinogenesis
Fishes
Apoptosis
Mutation
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

ASJC Scopus subject areas

  • Oncology
  • Drug Discovery
  • Pharmacology

Cite this

Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells. / Bachman, Kurtis E.; Sager, Jason; Cheong, Ian; Catto, Marco; Bardelli, Alberto; Park, Ben Ho; Vogelstein, Bert; Carotti, Angelo; Kinzler, Kenneth W.; Lengauer, Christoph.

In: Molecular Cancer Therapeutics, Vol. 4, No. 6, 06.2005, p. 1026-1030.

Research output: Contribution to journalArticle

Bachman, KE, Sager, J, Cheong, I, Catto, M, Bardelli, A, Park, BH, Vogelstein, B, Carotti, A, Kinzler, KW & Lengauer, C 2005, 'Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells', Molecular Cancer Therapeutics, vol. 4, no. 6, pp. 1026-1030. https://doi.org/10.1158/1535-7163.MCT-05-0038
Bachman, Kurtis E. ; Sager, Jason ; Cheong, Ian ; Catto, Marco ; Bardelli, Alberto ; Park, Ben Ho ; Vogelstein, Bert ; Carotti, Angelo ; Kinzler, Kenneth W. ; Lengauer, Christoph. / Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells. In: Molecular Cancer Therapeutics. 2005 ; Vol. 4, No. 6. pp. 1026-1030.
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