Identification of D-2 dopaminergic receptors in bovine adrenal cortex

Cristina Missale, Paolo Liberini, Maurizio Memo, Michele O. Carruba, PierFranco Spano

Research output: Contribution to journalArticlepeer-review

Abstract

Dopamine receptors in bovine adrenal cortex have been studied by using 3H-(-)sulpiride as selective ligand. The specific binding is saturable and the Scatchard analysis reveals a single component with a Kd of 6.2 nM and a Bmax of 8 fmoles/mg protein. The characterization indicates that the binding is rapid, reversible, stereospecific, Na+ - and temperature- dependent. Moreover its pharmacological profile is superimposable to that of D-2 receptors in the striatum, thus suggesting that central and peripheral D-2receptors are identical.

Original languageEnglish
Pages (from-to)2539-2548
Number of pages10
JournalLife Sciences
Volume37
Issue number26
DOIs
Publication statusPublished - Dec 30 1985

ASJC Scopus subject areas

  • Pharmacology

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