Abstract
Background-Cardiac resynchronization therapy (CRT) can improve ventricular size, shape, and mass and reduce mitral regurgitation by reverse remodeling of the failing ventricle. About 30% of patients do not respond to this therapy for unknown reasons. In this study, we aimed at the identification and classification of CRT responder by the use of genetic variants and clinical parameters. Methods and Results-Of 1421 CRT patients, 207 subjects were consecutively selected, and CRT responder and nonresponder were matched for their baseline parameters before CRT. Treatment success of CRT was defined as a decrease in left ventricular end-systolic volume >15% at follow-up echocardiography compared with left ventricular end-systolic volume at baseline. All other changes classified the patient as CRT nonresponder. A genetic association study was performed, which identified 4 genetic variants to be associated with the CRT responder phenotype at the allelic (P
| Original language | English |
|---|---|
| Pages (from-to) | 760-770 |
| Number of pages | 11 |
| Journal | Circulation: Cardiovascular Genetics |
| Volume | 7 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 1 2014 |
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Keywords
- Artificial intelligence
- Cardiac resynchronization therapy
- Cardiovascular disease
- Data mining
- Heart failure
- Risk factors
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Genetics(clinical)
- Genetics
- Medicine(all)
Cite this
Identification of genetic markers for treatment success in heart failure patients : Insight from cardiac resynchronization therapy. / Schmitz, Boris; De Maria, Renata; Gatsios, Dimitris; Chrysanthakopoulou, Theodora; Landolina, Maurizio; Gasparini, Maurizio; Campolo, Jonica; Parolini, Marina; Sanzo, Antonio; Galimberti, Paola; Bianchi, Michele; Lenders, Malte; Brand, Eva; Parodi, Oberdan; Lunati, Maurizio; Brand, Stefan Martin.
In: Circulation: Cardiovascular Genetics, Vol. 7, No. 6, 01.12.2014, p. 760-770.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of genetic markers for treatment success in heart failure patients
T2 - Insight from cardiac resynchronization therapy
AU - Schmitz, Boris
AU - De Maria, Renata
AU - Gatsios, Dimitris
AU - Chrysanthakopoulou, Theodora
AU - Landolina, Maurizio
AU - Gasparini, Maurizio
AU - Campolo, Jonica
AU - Parolini, Marina
AU - Sanzo, Antonio
AU - Galimberti, Paola
AU - Bianchi, Michele
AU - Lenders, Malte
AU - Brand, Eva
AU - Parodi, Oberdan
AU - Lunati, Maurizio
AU - Brand, Stefan Martin
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Background-Cardiac resynchronization therapy (CRT) can improve ventricular size, shape, and mass and reduce mitral regurgitation by reverse remodeling of the failing ventricle. About 30% of patients do not respond to this therapy for unknown reasons. In this study, we aimed at the identification and classification of CRT responder by the use of genetic variants and clinical parameters. Methods and Results-Of 1421 CRT patients, 207 subjects were consecutively selected, and CRT responder and nonresponder were matched for their baseline parameters before CRT. Treatment success of CRT was defined as a decrease in left ventricular end-systolic volume >15% at follow-up echocardiography compared with left ventricular end-systolic volume at baseline. All other changes classified the patient as CRT nonresponder. A genetic association study was performed, which identified 4 genetic variants to be associated with the CRT responder phenotype at the allelic (P
AB - Background-Cardiac resynchronization therapy (CRT) can improve ventricular size, shape, and mass and reduce mitral regurgitation by reverse remodeling of the failing ventricle. About 30% of patients do not respond to this therapy for unknown reasons. In this study, we aimed at the identification and classification of CRT responder by the use of genetic variants and clinical parameters. Methods and Results-Of 1421 CRT patients, 207 subjects were consecutively selected, and CRT responder and nonresponder were matched for their baseline parameters before CRT. Treatment success of CRT was defined as a decrease in left ventricular end-systolic volume >15% at follow-up echocardiography compared with left ventricular end-systolic volume at baseline. All other changes classified the patient as CRT nonresponder. A genetic association study was performed, which identified 4 genetic variants to be associated with the CRT responder phenotype at the allelic (P
KW - Artificial intelligence
KW - Cardiac resynchronization therapy
KW - Cardiovascular disease
KW - Data mining
KW - Heart failure
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=84925848392&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925848392&partnerID=8YFLogxK
U2 - 10.1161/CIRCGENETICS.113.000384
DO - 10.1161/CIRCGENETICS.113.000384
M3 - Article
VL - 7
SP - 760
EP - 770
JO - Circulation: Cardiovascular Genetics
JF - Circulation: Cardiovascular Genetics
SN - 1942-3268
IS - 6
ER -