Identification of microsomal metabolites of spirogermanium

Research output: Contribution to journalArticle

Abstract

In the present study we report on the identification of two novel microsomal metabolites of the investigational anticancer agent Spiroermanium (NSC-192965). The two metabolites were isolated after incubation of Spirogermanium with fortified rat liver microsomes. Mass spectrometry studies indicate that one of them, formed in major quantities, is hydroxy Spirogermanium. The other metabolite appears to correspond to bis - desmethylated Spirogermanium.

Original languageEnglish
Pages (from-to)507-510
Number of pages4
JournalAnticancer Research
Volume9
Issue number2
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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