Identification of motor and nonmotor wearing-off in Parkinson's disease: Comparison of a patient questionnaire versus a clinician assessment

Mark Stacy, Annette Bowron, Mark Guttman, Robert Hauser, Kim Hughes, Jan Petter Larsen, Peter Le Witt, Wolfgang Oertel, Niall Quinn, Kapil Sethi, Fabrizio Stocchi

Research output: Contribution to journalArticlepeer-review

Abstract

This study compares the sensitivity of a Patient Questionnaire versus information gathered by clinicians at a routine clinic visit in recognizing symptoms of wearing-off in early Parkinson's disease (PD). This Patient Questionnaire, containing 32 items representing a wide spectrum of motor and nonmotor wearing-off symptoms, was administered to subjects attending two PD clinics. The Patient Questionnaire results were compared to the information gathered by the clinician from the Unified Parkinson's Disease Rating Scale (UPDRS) Part IV, Question 36 and from a specific Clinical Assessment Question regarding loss of medication efficacy, wearing-off, sleepiness, dyskinesias, psychiatric complications, morning akinesia, other dopaminergic side effects, or none of the above. Examiners were blinded to study hypothesis and survey contents. Three hundred consecutive subjects with PD of

Original languageEnglish
Pages (from-to)726-733
Number of pages8
JournalMovement Disorders
Volume20
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Motor fluctuations
  • Parkinson's disease
  • Wearing-off

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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