The di-carboxylated derivative of spermidine, N-carboxyethyl γ-aminobutyric acid (CEGABA) has been identified in bovine brain and human cerebrospinal fluid by HPLC. This discovery strongly suggests the existence of a metabolic pathway connecting polyamines and GABA via putreanine and CEGABA through progressive oxidative deamination of the amino terminal groups in spermidine.
- Carboxyethyl γ-aminobutyric acid (CEGABA)
- GABA derivative
- Polyamine derivative
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