Identification of N-carboxyethyl γ-aminobutyric acid in bovine brain and human cerebrospinal fluid

F. Fussi, F. Savoldi, M. Curti

Research output: Contribution to journalArticlepeer-review

Abstract

The di-carboxylated derivative of spermidine, N-carboxyethyl γ-aminobutyric acid (CEGABA) has been identified in bovine brain and human cerebrospinal fluid by HPLC. This discovery strongly suggests the existence of a metabolic pathway connecting polyamines and GABA via putreanine and CEGABA through progressive oxidative deamination of the amino terminal groups in spermidine.

Original languageEnglish
Pages (from-to)308-310
Number of pages3
JournalNeuroscience Letters
Volume77
Issue number3
DOIs
Publication statusPublished - Jun 26 1987

Keywords

  • Carboxyethyl γ-aminobutyric acid (CEGABA)
  • GABA derivative
  • Polyamine derivative
  • Putreanine
  • Spermidine

ASJC Scopus subject areas

  • Neuroscience(all)

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