Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma

Annalisa Pezzolo; Valeria Capra; Alessandro Raso; Fabio Morandi; Federica Parodi; Claudio Gambini; Paolo Nozza; Felice Giangaspero; Armando Cama; Vito Pistoia; Maria Luisa Garrè

doi:10.1016/j.canlet.2007.11.021

Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma

Annalisa Pezzolo, Valeria Capra, Alessandro Raso, Fabio Morandi, Federica Parodi, Claudio Gambini, Paolo Nozza, Felice Giangaspero, Armando Cama, Vito Pistoia, Maria Luisa Garrè

Research output: Contribution to journal › Article

Abstract

Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma. Tumor DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades II and III), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). The novel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2-q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p13.1-p13.3 gain. The combined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings.

Original language	English
Pages (from-to)	235-243
Number of pages	9
Journal	Cancer Letters
Volume	261
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2007.11.021
Publication status	Published - Mar 18 2008

Keywords

CGH
Chromosomal imbalances
Ependymoma
FISH
Infant brain tumors

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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Pezzolo, A., Capra, V., Raso, A., Morandi, F., Parodi, F., Gambini, C., Nozza, P., Giangaspero, F., Cama, A., Pistoia, V., & Garrè, M. L. (2008). Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma. Cancer Letters, 261(2), 235-243. https://doi.org/10.1016/j.canlet.2007.11.021

Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma. / Pezzolo, Annalisa ; Capra, Valeria; Raso, Alessandro; Morandi, Fabio; Parodi, Federica; Gambini, Claudio; Nozza, Paolo ; Giangaspero, Felice ; Cama, Armando; Pistoia, Vito; Garrè, Maria Luisa.

In: Cancer Letters, Vol. 261, No. 2, 18.03.2008, p. 235-243.

Research output: Contribution to journal › Article

Pezzolo, Annalisa ; Capra, Valeria ; Raso, Alessandro ; Morandi, Fabio ; Parodi, Federica ; Gambini, Claudio ; Nozza, Paolo ; Giangaspero, Felice ; Cama, Armando ; Pistoia, Vito ; Garrè, Maria Luisa. / Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma. In: Cancer Letters. 2008 ; Vol. 261, No. 2. pp. 235-243.

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keywords = "CGH, Chromosomal imbalances, Ependymoma, FISH, Infant brain tumors",

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AU - Parodi, Federica

AU - Gambini, Claudio

AU - Nozza, Paolo

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AB - Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma. Tumor DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades II and III), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). The novel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2-q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p13.1-p13.3 gain. The combined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings.

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