Abstract
Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma. Tumor DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades II and III), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). The novel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2-q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p13.1-p13.3 gain. The combined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings.
Original language | English |
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Pages (from-to) | 235-243 |
Number of pages | 9 |
Journal | Cancer Letters |
Volume | 261 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 18 2008 |
Keywords
- CGH
- Chromosomal imbalances
- Ependymoma
- FISH
- Infant brain tumors
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology