Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma

Annalisa Pezzolo; Valeria Capra; Alessandro Raso; Fabio Morandi; Federica Parodi; Claudio Gambini; Paolo Nozza; Felice Giangaspero; Armando Cama; Vito Pistoia; Maria Luisa Garrè

doi:10.1016/j.canlet.2007.11.021

Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma

Annalisa Pezzolo, Valeria Capra, Alessandro Raso, Fabio Morandi, Federica Parodi, Claudio Gambini, Paolo Nozza, Felice Giangaspero, Armando Cama, Vito Pistoia, Maria Luisa Garrè

Research output: Contribution to journal › Article › peer-review

Abstract

Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma. Tumor DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades II and III), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). The novel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2-q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p13.1-p13.3 gain. The combined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings.

Original language	English
Pages (from-to)	235-243
Number of pages	9
Journal	Cancer Letters
Volume	261
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2007.11.021
Publication status	Published - Mar 18 2008

Keywords

CGH
Chromosomal imbalances
Ependymoma
FISH
Infant brain tumors

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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10.1016/j.canlet.2007.11.021

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title = "Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma",

abstract = "Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma. Tumor DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades II and III), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). The novel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2-q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p13.1-p13.3 gain. The combined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings.",

keywords = "CGH, Chromosomal imbalances, Ependymoma, FISH, Infant brain tumors",

author = "Annalisa Pezzolo and Valeria Capra and Alessandro Raso and Fabio Morandi and Federica Parodi and Claudio Gambini and Paolo Nozza and Felice Giangaspero and Armando Cama and Vito Pistoia and Garr{\`e}, {Maria Luisa}",

year = "2008",

month = mar,

day = "18",

doi = "10.1016/j.canlet.2007.11.021",

language = "English",

volume = "261",

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journal = "Cancer Letters",

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T1 - Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma

AU - Pezzolo, Annalisa

AU - Capra, Valeria

AU - Raso, Alessandro

AU - Morandi, Fabio

AU - Parodi, Federica

AU - Gambini, Claudio

AU - Nozza, Paolo

AU - Giangaspero, Felice

AU - Cama, Armando

AU - Pistoia, Vito

AU - Garrè, Maria Luisa

PY - 2008/3/18

Y1 - 2008/3/18

N2 - Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma. Tumor DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades II and III), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). The novel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2-q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p13.1-p13.3 gain. The combined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings.

AB - Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma. Tumor DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades II and III), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). The novel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2-q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p13.1-p13.3 gain. The combined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings.

KW - CGH

KW - Chromosomal imbalances

KW - Ependymoma

KW - FISH

KW - Infant brain tumors

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JO - Cancer Letters

JF - Cancer Letters

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Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma

Abstract

Keywords

ASJC Scopus subject areas

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