Identification of Preleukemic Precursors of Hyperdiploid Acute Lymphoblastic Leukemia in Cord Blood

Ana Teresa Maia, Roxane Tussiwand, Giovanni Cazzaniga, Paolo Rebulla, Susan Colman, Andrea Biondi, Mel Greaves

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies involving identical twins with concordant leukemia and retrospective scrutiny of archived neonatal blood spots have shown that common chromosome translocations of pediatric leukemia frequently arise before birth. The IGHITCR clonotypic sequences used as surrogate molecular markers suggest this is also likely to be true for hyperdiploid acute lymphoblastic leukemia (ALL). Yet evidence that hyperdiploidy itself is an early or initiating event occurring prenatally has been limited. Now, however, we can provide direct evidence of this from our identification of CD34 +/CD19 + B-lineage progenitor cells with triploid chromosomes in the stored cord blood of an individual who subsequently developed hyperdiploid ALL.

Original languageEnglish
Pages (from-to)38-43
Number of pages6
JournalGenes Chromosomes and Cancer
Volume40
Issue number1
DOIs
Publication statusPublished - May 2004

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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