Identification of prognostic factors predicting outcome in Hodgkin's lymphoma patients relapsing after autologous stem cell transplantation

C. Martínez, C. Canals, B. Sarina, E. P. Alessandrino, D. Karakasis, A. Pulsoni, S. Sica, M. Trneny, J. A. Snowden, E. Kanfer, N. Milpied, A. Bosi, S. Guidi, C. A. De Souza, R. Willemze, R. Arranz, L. Jebavy, A. Hellmann, D. Sibon, R. OnetoJ. J. Luan, P. Dreger, L. Castagna, A. Sureda

Research output: Contribution to journalArticle

Abstract

Background: High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard of care for patients with relapsed Hodgkin's lymphoma (HL). However, there is currently little information on the predictors of outcome for patients whose disease recurs after ASCT. Methods: Five hundred and eleven adult patients with relapsed HL after ASCT from EBMT-GITMO databases were reviewed. Results: Treatments administered following ASCT failure included conventional chemotherapy and/or radiotherapy in 294 (64%) patients, second ASCT in 35 (8%), and alloSCT in 133 (29%). After a median follow-up of 49 months, overall survival (OS) was 32% at 5 years. Independent risk factors for OS were early relapse (

Original languageEnglish
Article numbermdt206
Pages (from-to)2430-2434
Number of pages5
JournalAnnals of Oncology
Volume24
Issue number9
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Autologous stem cell transplantation
  • Hodgkin's lymphoma
  • Relapse

ASJC Scopus subject areas

  • Oncology
  • Hematology

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    Martínez, C., Canals, C., Sarina, B., Alessandrino, E. P., Karakasis, D., Pulsoni, A., Sica, S., Trneny, M., Snowden, J. A., Kanfer, E., Milpied, N., Bosi, A., Guidi, S., De Souza, C. A., Willemze, R., Arranz, R., Jebavy, L., Hellmann, A., Sibon, D., ... Sureda, A. (2013). Identification of prognostic factors predicting outcome in Hodgkin's lymphoma patients relapsing after autologous stem cell transplantation. Annals of Oncology, 24(9), 2430-2434. [mdt206]. https://doi.org/10.1093/annonc/mdt206