Identification of PTEN-related sequences in glioma cells and in non-neoplastic cell lines

Elena Chiariello, Luca Roz, Ruth Albarosa, Ivana Magnani, Gaetano Finocchiaro

Research output: Contribution to journalArticlepeer-review

Abstract

The PTEN gene, which encodes a tumor suppressor with phosphatase activity, is located on chromosome 10q23 and is mutated in different tumors, including glioblastomas (GBM). We found evidence for a PTEN-related sequence (PTEN-rs) on genomic DNA of GBM and non-neoplastic cells. PTEN-rs does not contain introns and presents several conserved missense mutations, including a T to G transversion at the initiation codon. Rsa I digestion may help to identify this putative PTEN pseudogene which, according to RT-PCR analysis on glioma, fibroblast, brain and lung cells, does not appear to be transcribed. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalCancer Letters
Volume138
Issue number1-2
DOIs
Publication statusPublished - Apr 26 1999

Keywords

  • Glioma
  • Pseudogene
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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