Abstract
The lack of expression of the putative tumor suppressor gene DMBT1 has been described in gliomas, lung carcinomas, and other malignancies. To investigate the mechanisms regulating DMBT1 expression we have screened a human genomic library with a 5' cDNA probe and identified a fragment of approximately 3 kb upstream of the proposed coding sequence of DMBT1. This fragment contains subregions that may up- or down-regulate the expression of a reporter gene. These findings may help to elucidate the mechanisms regulating the alternative splicing and the tissue specific expression of DMBT1. (C) 2000 Academic Press.
| Original language | English |
|---|---|
| Pages (from-to) | 673-675 |
| Number of pages | 3 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 270 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 13 2000 |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Identification of regulatory regions of the putative tumor suppressor gene DMBT1. / Lualdi, E.; Chiariello, E.; Finocchiaro, G.
In: Biochemical and Biophysical Research Communications, Vol. 270, No. 2, 13.04.2000, p. 673-675.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of regulatory regions of the putative tumor suppressor gene DMBT1
AU - Lualdi, E.
AU - Chiariello, E.
AU - Finocchiaro, G.
PY - 2000/4/13
Y1 - 2000/4/13
N2 - The lack of expression of the putative tumor suppressor gene DMBT1 has been described in gliomas, lung carcinomas, and other malignancies. To investigate the mechanisms regulating DMBT1 expression we have screened a human genomic library with a 5' cDNA probe and identified a fragment of approximately 3 kb upstream of the proposed coding sequence of DMBT1. This fragment contains subregions that may up- or down-regulate the expression of a reporter gene. These findings may help to elucidate the mechanisms regulating the alternative splicing and the tissue specific expression of DMBT1. (C) 2000 Academic Press.
AB - The lack of expression of the putative tumor suppressor gene DMBT1 has been described in gliomas, lung carcinomas, and other malignancies. To investigate the mechanisms regulating DMBT1 expression we have screened a human genomic library with a 5' cDNA probe and identified a fragment of approximately 3 kb upstream of the proposed coding sequence of DMBT1. This fragment contains subregions that may up- or down-regulate the expression of a reporter gene. These findings may help to elucidate the mechanisms regulating the alternative splicing and the tissue specific expression of DMBT1. (C) 2000 Academic Press.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034643286&partnerID=8YFLogxK
U2 - 10.1006/bbrc.2000.2478
DO - 10.1006/bbrc.2000.2478
M3 - Article
C2 - 10753682
AN - SCOPUS:0034643286
VL - 270
SP - 673
EP - 675
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -