Identification of regulatory regions of the putative tumor suppressor gene DMBT1

E. Lualdi, E. Chiariello, G. Finocchiaro

Research output: Contribution to journalArticle

Abstract

The lack of expression of the putative tumor suppressor gene DMBT1 has been described in gliomas, lung carcinomas, and other malignancies. To investigate the mechanisms regulating DMBT1 expression we have screened a human genomic library with a 5' cDNA probe and identified a fragment of approximately 3 kb upstream of the proposed coding sequence of DMBT1. This fragment contains subregions that may up- or down-regulate the expression of a reporter gene. These findings may help to elucidate the mechanisms regulating the alternative splicing and the tissue specific expression of DMBT1. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)673-675
Number of pages3
JournalBiochemical and Biophysical Research Communications
Volume270
Issue number2
DOIs
Publication statusPublished - Apr 13 2000

Fingerprint

Genomic Library
Nucleic Acid Regulatory Sequences
Alternative Splicing
Tumor Suppressor Genes
Reporter Genes
Glioma
Tumors
Up-Regulation
Down-Regulation
Complementary DNA
Genes
Carcinoma
Lung
Neoplasms
Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Identification of regulatory regions of the putative tumor suppressor gene DMBT1. / Lualdi, E.; Chiariello, E.; Finocchiaro, G.

In: Biochemical and Biophysical Research Communications, Vol. 270, No. 2, 13.04.2000, p. 673-675.

Research output: Contribution to journalArticle

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