Identificazione di danno renale reversibile e di precoce risposta alla chemioterapia in pazienti con amiloidosi AL

Translated title of the contribution: Identification of reversible renal damage and early response to chemotherapy in AL amyloidosis

Paolo Milani, Giovanni Palladini, Ute Hegenbart, Christoph Kimmich, Andrea Foli, Anthony D. Ho, Marta Vidus Rosin, Riccardo Albertini, Remigio Moratti, Stefan Schönland, Giampaolo Merlini

Research output: Contribution to journalArticle

Abstract

The kidney is involved in 70% of patients with immunoglobulin light-chain (AL) amyloidosis, but little is known on progression or reversibility of renal involvement. Furthermore, criteria for renal response have never been validated. We designed a staging system for renal damage and identified criteria for renal response and progression in a population of 732 newly diagnosed patients with AL amyloidosis. The population was composed of 461 patients from Pavia (testing cohort) and 271 subjects from Heidelberg (validation cohort). Baseline proteinuria >5 g/24 h and estimated glomerular filtration rate (eGFR)

Translated title of the contributionIdentification of reversible renal damage and early response to chemotherapy in AL amyloidosis
Original languageItalian
Pages (from-to)21-27
Number of pages7
JournalBiochimica Clinica
Volume40
Issue number1
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medical Laboratory Technology

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