Identification of specific gait patterns in patients with cerebellar ataxia, spastic paraplegia, and Parkinson's disease: A non-hierarchical cluster analysis

Mariano Serrao, Giorgia Chini, Matteo Bergantino, Diego Sarnari, Carlo Casali, Carmela Conte, Alberto Ranavolo, Christian Marcotulli, Martina Rinaldi, Gianluca Coppola, Fabiano Bini, Francesco Pierelli, Franco Marinozzi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Patients with degenerative neurological diseases such as cerebellar ataxia, spastic paraplegia, and Parkinson's disease often display progressive gait function decline that inexorably impacts their autonomy and quality of life. Therefore, considering the related social and economic costs, one of the most important areas of intervention in neurorehabilitation should be the treatment of gait abnormalities. This study aims to determine whether an entire dataset of gait parameters recorded in patients with degenerative neurological diseases can be clustered into homogeneous groups distinct from each other and from healthy subjects. Patients affected by three different types of primary degenerative neurological diseases were studied. These diseases were: i) cerebellar ataxia (28 patients), ii) hereditary spastic paraplegia (31 patients), and iii) Parkinson's disease (70 patients). Sixty-five gender-age-matched healthy subjects were enrolled as a control group. An optoelectronic motion analysis system was used to measure time-distance parameters and lower limb joint kinematics during gait in both patients and healthy controls. When clustering single parameters, step width and ankle joint range of motion (RoM) in the sagittal plane differentiated cerebellar ataxia group from the other groups. When clustering sets of two, three, or four parameters, several pairs, triples, and quadruples of clusters differentiated the cerebellar ataxia group from the other groups. Interestingly, the ankle joint RoM parameter was present in 100% of the clusters and the step width in approximately 50% of clusters. In addition, in almost all clusters, patients with cerebellar ataxia showed the lowest ankle joint RoM and the largest step width values compared to healthy controls, patients with hereditary spastic paraplegia, and Parkinson's disease subjects. This study identified several clusters reflecting specific gait patterns in patients with degenerative neurological diseases. In particular, the specific gait pattern formed by the increased step width, reduced ankle joint RoM, and increased gait variability, can differentiate patients with cerebellar ataxia from healthy subjects and patients with spastic paraplegia or Parkinson's disease. These abnormal parameters may be adopted as sensitive tools for evaluating the effect of pharmacological and rehabilitative treatments.

Original languageEnglish
JournalHuman Movement Science
DOIs
Publication statusE-pub ahead of print - Sep 2017

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Cerebellar Ataxia
Paraplegia
Gait
Cluster Analysis
Parkinson Disease
Ankle Joint
Articular Range of Motion
Hereditary Spastic Paraplegia
Healthy Volunteers
Biomechanical Phenomena
Lower Extremity
Joints

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Experimental and Cognitive Psychology

Cite this

Identification of specific gait patterns in patients with cerebellar ataxia, spastic paraplegia, and Parkinson's disease : A non-hierarchical cluster analysis. / Serrao, Mariano; Chini, Giorgia; Bergantino, Matteo; Sarnari, Diego; Casali, Carlo; Conte, Carmela; Ranavolo, Alberto; Marcotulli, Christian; Rinaldi, Martina; Coppola, Gianluca; Bini, Fabiano; Pierelli, Francesco; Marinozzi, Franco.

In: Human Movement Science, 09.2017.

Research output: Contribution to journalArticle

Serrao, Mariano ; Chini, Giorgia ; Bergantino, Matteo ; Sarnari, Diego ; Casali, Carlo ; Conte, Carmela ; Ranavolo, Alberto ; Marcotulli, Christian ; Rinaldi, Martina ; Coppola, Gianluca ; Bini, Fabiano ; Pierelli, Francesco ; Marinozzi, Franco. / Identification of specific gait patterns in patients with cerebellar ataxia, spastic paraplegia, and Parkinson's disease : A non-hierarchical cluster analysis. In: Human Movement Science. 2017.
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AU - Chini, Giorgia

AU - Bergantino, Matteo

AU - Sarnari, Diego

AU - Casali, Carlo

AU - Conte, Carmela

AU - Ranavolo, Alberto

AU - Marcotulli, Christian

AU - Rinaldi, Martina

AU - Coppola, Gianluca

AU - Bini, Fabiano

AU - Pierelli, Francesco

AU - Marinozzi, Franco

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N2 - Background: Patients with degenerative neurological diseases such as cerebellar ataxia, spastic paraplegia, and Parkinson's disease often display progressive gait function decline that inexorably impacts their autonomy and quality of life. Therefore, considering the related social and economic costs, one of the most important areas of intervention in neurorehabilitation should be the treatment of gait abnormalities. This study aims to determine whether an entire dataset of gait parameters recorded in patients with degenerative neurological diseases can be clustered into homogeneous groups distinct from each other and from healthy subjects. Patients affected by three different types of primary degenerative neurological diseases were studied. These diseases were: i) cerebellar ataxia (28 patients), ii) hereditary spastic paraplegia (31 patients), and iii) Parkinson's disease (70 patients). Sixty-five gender-age-matched healthy subjects were enrolled as a control group. An optoelectronic motion analysis system was used to measure time-distance parameters and lower limb joint kinematics during gait in both patients and healthy controls. When clustering single parameters, step width and ankle joint range of motion (RoM) in the sagittal plane differentiated cerebellar ataxia group from the other groups. When clustering sets of two, three, or four parameters, several pairs, triples, and quadruples of clusters differentiated the cerebellar ataxia group from the other groups. Interestingly, the ankle joint RoM parameter was present in 100% of the clusters and the step width in approximately 50% of clusters. In addition, in almost all clusters, patients with cerebellar ataxia showed the lowest ankle joint RoM and the largest step width values compared to healthy controls, patients with hereditary spastic paraplegia, and Parkinson's disease subjects. This study identified several clusters reflecting specific gait patterns in patients with degenerative neurological diseases. In particular, the specific gait pattern formed by the increased step width, reduced ankle joint RoM, and increased gait variability, can differentiate patients with cerebellar ataxia from healthy subjects and patients with spastic paraplegia or Parkinson's disease. These abnormal parameters may be adopted as sensitive tools for evaluating the effect of pharmacological and rehabilitative treatments.

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