Identification of the ferroxidase centre in ferritin

David M. Lawson, Amyra Treffry, Peter J. Artymiuk, Pauline M. Harrison, Stephen J. Yewdall, Alessandra Luzzago, Gianne Cesareni, Sonia Levi, Paolo Arosio

Research output: Contribution to journalArticlepeer-review


Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalFEBS Letters
Issue number1-2
Publication statusPublished - Aug 28 1989


  • Enzyme activity
  • Ferritin
  • Ferritin, recombinant
  • Ferroxidase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Cell Biology
  • Genetics
  • Structural Biology


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