Identification of the ferroxidase centre in ferritin

David M. Lawson; Amyra Treffry; Peter J. Artymiuk; Pauline M. Harrison; Stephen J. Yewdall; Alessandra Luzzago; Gianne Cesareni; Sonia Levi; Paolo Arosio

doi:10.1016/0014-5793(89)81040-3

Identification of the ferroxidase centre in ferritin

David M. Lawson, Amyra Treffry, Peter J. Artymiuk, Pauline M. Harrison, Stephen J. Yewdall, Alessandra Luzzago, Gianne Cesareni, Sonia Levi, Paolo Arosio

Research output: Contribution to journal › Article › peer-review

Abstract

Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.

Original language	English
Pages (from-to)	207-210
Number of pages	4
Journal	FEBS Letters
Volume	254
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(89)81040-3
Publication status	Published - Aug 28 1989

Keywords

Enzyme activity
Ferritin
Ferritin, recombinant
Ferroxidase

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology
Cell Biology
Genetics
Structural Biology

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10.1016/0014-5793(89)81040-3

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title = "Identification of the ferroxidase centre in ferritin",

abstract = "Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.",

keywords = "Enzyme activity, Ferritin, Ferritin, recombinant, Ferroxidase",

author = "Lawson, {David M.} and Amyra Treffry and Artymiuk, {Peter J.} and Harrison, {Pauline M.} and Yewdall, {Stephen J.} and Alessandra Luzzago and Gianne Cesareni and Sonia Levi and Paolo Arosio",

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doi = "10.1016/0014-5793(89)81040-3",

language = "English",

volume = "254",

pages = "207--210",

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T1 - Identification of the ferroxidase centre in ferritin

AU - Lawson, David M.

AU - Treffry, Amyra

AU - Artymiuk, Peter J.

AU - Harrison, Pauline M.

AU - Yewdall, Stephen J.

AU - Luzzago, Alessandra

AU - Cesareni, Gianne

AU - Levi, Sonia

AU - Arosio, Paolo

PY - 1989/8/28

Y1 - 1989/8/28

N2 - Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.

AB - Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.

KW - Enzyme activity

KW - Ferritin

KW - Ferritin, recombinant

KW - Ferroxidase

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SP - 207

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JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

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