Identification of the glial cell types containing carnosine-related peptides in the rat brain

Silvia De Marchis, Roberto Cosimo Melcangi, Chiara Modena, Ilaria Cavaretta, Paolo Peretto, Cristina Agresti, Aldo Fasolo

Research output: Contribution to journalArticlepeer-review


The cellular localization of carnosine-like immunoreactivity was investigated in the adult rat forebrain and in glial cell cultures obtained from newborn rat brain. Using double staining methods, we showed that in vivo carnosine-like immunoreactivity was occurring in a large number of both glial fibrillary acidic protein (GFAP)-positive astrocytes and 2'3'-cyclic nucleotide 3'-phosphodiesterase (CNP)-positive oligodendrocytes. In vitro, the carnosine-immunoreactive staining was restricted to a subpopulation of completely differentiated oligodendrocytes, whereas no reaction was detected in immature oligodendrocytes and in astrocytes. These observations could have profound physiopathological Implications considering the role suggested for carnosine and related peptides as endogenous antioxidants, free radical scavengers and anti-glycating agents of the central nervous system (CNS).

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - Nov 14 1997


  • Astrocytes
  • Carnosine
  • Cell culture
  • Central nervous system
  • Immunocytochemistry
  • Oligodendrocytes
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)


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