Identification of the novel KI polyomavirus in the respiratory tract of an Italian patient

Muhammed Babakir-Mina, Massimo Ciccozzi, Salvatore Dimonte, Francesca Farchi, Catia Valdarchi, Giovanni Rezza, Carlo Federico Perno, Marco Ciotti

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, a new human polyomavirus, KIV, was detected in respiratory specimens of patients with acute respiratory tract infection. Whether this reflects a causal role of the virus in the respiratory tract is still debated. To investigate the presence of KIV in respiratory samples of Italian patients and to determine the degree of similarity with other known polyomaviruses, 222 respiratory specimens collected by general practitioners between 2006 and 2007 were screened. The entire VP1 gene region was amplified and sequenced. Maximum Likelihood tree was generated by PAUP* software. One out of 222 samples tested was positive for KIV. Phylogenetic analysis indicated that this isolate clustered with other KIV isolates, while the WUV isolates seem to belong to a different lineage. The phylogenetic tree also showed that all other known polyomaviruses are quite distant from this isolate. This is the first report describing the presence of KIV in the respiratory tract of a 5-year-old Italian child with acute respiratory symptoms. Further investigations are needed to establish an etiological link of KIV with acute respiratory illness.

Original languageEnglish
Pages (from-to)2012-2014
Number of pages3
JournalJournal of Medical Virology
Volume80
Issue number11
DOIs
Publication statusPublished - Nov 2008

Keywords

  • KIV polyomavirus
  • Molecular epidemiology
  • Respiratory tract infection

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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