Identification of the Syrian hamster cardiomyopathy gene

Vincenzo Nigro, Yasushi Okazaki, Angela Belsito, Giulio Piluso, Yoichi Matsuda, Luisa Politano, Giovanni Nigro, Carlo Ventura, Ciro Abbondanza, Anna Maria Molinari, Dario Acampora, Masahiko Nishimura, Yoshihide Hayashizaki, Giovanni Alfredo Puca

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

The BIO14.6 hamster is a widely used model for autosomal recessive cardiomyopathy. These animals die prematurely from progressive myocardial necrosis and heart failure. The primary genetic defect leading to the cardiomyopathy is still unknown. Recently, a genetic linkage map localized the cardiomyopathy locus on hamster chromosome 9qa2.1-b1, excluding several candidate genes. We now demonstrate that the cardiomyopathy results from a mutation in the δ-sarcoglycan gene that maps to the disease locus. This mutation was completely coincident with the disease in backcross and F2 pedigrees. This constitutes the first animal model identified for human sarcoglycan disorders.

Original languageEnglish
Pages (from-to)601-607
Number of pages7
JournalHuman Molecular Genetics
Volume6
Issue number4
DOIs
Publication statusPublished - Apr 1997

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Mesocricetus
Cardiomyopathies
Sarcoglycans
Cricetinae
Genes
Heart Failure
Mutation
Genetic Linkage
Pedigree
Necrosis
Animal Models
Chromosomes

ASJC Scopus subject areas

  • Genetics

Cite this

Nigro, V., Okazaki, Y., Belsito, A., Piluso, G., Matsuda, Y., Politano, L., ... Puca, G. A. (1997). Identification of the Syrian hamster cardiomyopathy gene. Human Molecular Genetics, 6(4), 601-607. https://doi.org/10.1093/hmg/6.4.601

Identification of the Syrian hamster cardiomyopathy gene. / Nigro, Vincenzo; Okazaki, Yasushi; Belsito, Angela; Piluso, Giulio; Matsuda, Yoichi; Politano, Luisa; Nigro, Giovanni; Ventura, Carlo; Abbondanza, Ciro; Molinari, Anna Maria; Acampora, Dario; Nishimura, Masahiko; Hayashizaki, Yoshihide; Puca, Giovanni Alfredo.

In: Human Molecular Genetics, Vol. 6, No. 4, 04.1997, p. 601-607.

Research output: Contribution to journalArticle

Nigro, V, Okazaki, Y, Belsito, A, Piluso, G, Matsuda, Y, Politano, L, Nigro, G, Ventura, C, Abbondanza, C, Molinari, AM, Acampora, D, Nishimura, M, Hayashizaki, Y & Puca, GA 1997, 'Identification of the Syrian hamster cardiomyopathy gene', Human Molecular Genetics, vol. 6, no. 4, pp. 601-607. https://doi.org/10.1093/hmg/6.4.601
Nigro V, Okazaki Y, Belsito A, Piluso G, Matsuda Y, Politano L et al. Identification of the Syrian hamster cardiomyopathy gene. Human Molecular Genetics. 1997 Apr;6(4):601-607. https://doi.org/10.1093/hmg/6.4.601
Nigro, Vincenzo ; Okazaki, Yasushi ; Belsito, Angela ; Piluso, Giulio ; Matsuda, Yoichi ; Politano, Luisa ; Nigro, Giovanni ; Ventura, Carlo ; Abbondanza, Ciro ; Molinari, Anna Maria ; Acampora, Dario ; Nishimura, Masahiko ; Hayashizaki, Yoshihide ; Puca, Giovanni Alfredo. / Identification of the Syrian hamster cardiomyopathy gene. In: Human Molecular Genetics. 1997 ; Vol. 6, No. 4. pp. 601-607.
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