Identification of the Syrian hamster cardiomyopathy gene

Vincenzo Nigro; Yasushi Okazaki; Angela Belsito; Giulio Piluso; Yoichi Matsuda; Luisa Politano; Giovanni Nigro; Carlo Ventura; Ciro Abbondanza; Anna Maria Molinari; Dario Acampora; Masahiko Nishimura; Yoshihide Hayashizaki; Giovanni Alfredo Puca

doi:10.1093/hmg/6.4.601

Identification of the Syrian hamster cardiomyopathy gene

Vincenzo Nigro, Yasushi Okazaki, Angela Belsito, Giulio Piluso, Yoichi Matsuda, Luisa Politano, Giovanni Nigro, Carlo Ventura, Ciro Abbondanza, Anna Maria Molinari, Dario Acampora, Masahiko Nishimura, Yoshihide Hayashizaki, Giovanni Alfredo Puca

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Abstract

The BIO14.6 hamster is a widely used model for autosomal recessive cardiomyopathy. These animals die prematurely from progressive myocardial necrosis and heart failure. The primary genetic defect leading to the cardiomyopathy is still unknown. Recently, a genetic linkage map localized the cardiomyopathy locus on hamster chromosome 9qa2.1-b1, excluding several candidate genes. We now demonstrate that the cardiomyopathy results from a mutation in the δ-sarcoglycan gene that maps to the disease locus. This mutation was completely coincident with the disease in backcross and F₂ pedigrees. This constitutes the first animal model identified for human sarcoglycan disorders.

Original language	English
Pages (from-to)	601-607
Number of pages	7
Journal	Human Molecular Genetics
Volume	6
Issue number	4
DOIs	https://doi.org/10.1093/hmg/6.4.601
Publication status	Published - Apr 1997

ASJC Scopus subject areas

Genetics

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Identification of the Syrian hamster cardiomyopathy gene. / Nigro, Vincenzo; Okazaki, Yasushi; Belsito, Angela; Piluso, Giulio; Matsuda, Yoichi; Politano, Luisa; Nigro, Giovanni; Ventura, Carlo; Abbondanza, Ciro; Molinari, Anna Maria; Acampora, Dario; Nishimura, Masahiko; Hayashizaki, Yoshihide; Puca, Giovanni Alfredo.

In: Human Molecular Genetics, Vol. 6, No. 4, 04.1997, p. 601-607.

Research output: Contribution to journal › Article › peer-review

Nigro, Vincenzo ; Okazaki, Yasushi ; Belsito, Angela ; Piluso, Giulio ; Matsuda, Yoichi ; Politano, Luisa ; Nigro, Giovanni ; Ventura, Carlo ; Abbondanza, Ciro ; Molinari, Anna Maria ; Acampora, Dario ; Nishimura, Masahiko ; Hayashizaki, Yoshihide ; Puca, Giovanni Alfredo. / Identification of the Syrian hamster cardiomyopathy gene. In: Human Molecular Genetics. 1997 ; Vol. 6, No. 4. pp. 601-607.

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AU - Nigro, Giovanni

AU - Ventura, Carlo

AU - Abbondanza, Ciro

AU - Molinari, Anna Maria

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Identification of the Syrian hamster cardiomyopathy gene

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