TY - JOUR
T1 - Identification of the TCL1 gene involved in T-cell malignancies
AU - Virgilio, Laura
AU - Narducci, Maria Grazia
AU - Isobe, Masaharu
AU - Billips, Linda G.
AU - Cooper, Max D.
AU - Croce, Carlo M.
AU - Russo, Giandomenico
PY - 1994/12/20
Y1 - 1994/12/20
N2 - The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell leukemias and lymphomas. The chromosome 14 region translocated or rearranged involves ≃350 kb of DNA at chromosome band 14q32.1. Within this region we have identified a gene coding for a 1.3-kb transcript, expressed only in restricted subsets of cells within the lymphoid lineage and expressed at high levels in leukemic cells carrying a t(14;14)(q11;q32) chromosome translocation or a inv(14)(q11;q32) chromosome inversion. The cognate cDNA sequence reveals an open reading frame of 342 nt encoding a protein of 14 kDa. The TCLI gene sequence, which, to our knowledge, shows no sequence homology with other human genes, is preferentially expressed early in T- and B-lymphocyte differentiation.
AB - The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell leukemias and lymphomas. The chromosome 14 region translocated or rearranged involves ≃350 kb of DNA at chromosome band 14q32.1. Within this region we have identified a gene coding for a 1.3-kb transcript, expressed only in restricted subsets of cells within the lymphoid lineage and expressed at high levels in leukemic cells carrying a t(14;14)(q11;q32) chromosome translocation or a inv(14)(q11;q32) chromosome inversion. The cognate cDNA sequence reveals an open reading frame of 342 nt encoding a protein of 14 kDa. The TCLI gene sequence, which, to our knowledge, shows no sequence homology with other human genes, is preferentially expressed early in T- and B-lymphocyte differentiation.
KW - B-cell differentiation
KW - chromosome 14q32.1
KW - lymphoid malignancies
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U2 - 10.1073/pnas.91.26.12530
DO - 10.1073/pnas.91.26.12530
M3 - Article
C2 - 7809072
AN - SCOPUS:0028587370
VL - 91
SP - 12530
EP - 12534
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 26
ER -