Identification of the TCL1 gene involved in T-cell malignancies

Laura Virgilio, Maria Grazia Narducci, Masaharu Isobe, Linda G. Billips, Max D. Cooper, Carlo M. Croce, Giandomenico Russo

Research output: Contribution to journalArticlepeer-review

Abstract

The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell leukemias and lymphomas. The chromosome 14 region translocated or rearranged involves ≃350 kb of DNA at chromosome band 14q32.1. Within this region we have identified a gene coding for a 1.3-kb transcript, expressed only in restricted subsets of cells within the lymphoid lineage and expressed at high levels in leukemic cells carrying a t(14;14)(q11;q32) chromosome translocation or a inv(14)(q11;q32) chromosome inversion. The cognate cDNA sequence reveals an open reading frame of 342 nt encoding a protein of 14 kDa. The TCLI gene sequence, which, to our knowledge, shows no sequence homology with other human genes, is preferentially expressed early in T- and B-lymphocyte differentiation.

Original languageEnglish
Pages (from-to)12530-12534
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number26
DOIs
Publication statusPublished - Dec 20 1994

Keywords

  • B-cell differentiation
  • chromosome 14q32.1
  • lymphoid malignancies

ASJC Scopus subject areas

  • Genetics
  • General

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