Identification of trophoblast in chorionic villi biopsy samples

Angela E. Covone, P. M. Johnson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We have investigated a test for rapid discrimination between foetal and maternal origin of chorionic villi biopsy samples. A monoclonal antibody named H315 reacting against a specific antigen present on the surface of foetal trophoblastic cells, plus a double-colour staining technique (FITC + PI), have been used for the identification of foetal cells (H315-positive) and for visualization of nucleate (PI-positive) and anucleate (PI-negative) structures of chorionic villi. This test could be useful in differentiating foetal and maternal cells in chorionic villi biopsy samples currently used for prenatal diagnostic purposes.

Original languageEnglish
Pages (from-to)172-173
Number of pages2
JournalHuman Genetics
Volume72
Issue number2
DOIs
Publication statusPublished - Feb 1986

Fingerprint

Chorionic Villi Sampling
Trophoblasts
Mothers
Chorionic Villi
Fluorescein-5-isothiocyanate
Color
Monoclonal Antibodies
Staining and Labeling
Antigens

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Identification of trophoblast in chorionic villi biopsy samples. / Covone, Angela E.; Johnson, P. M.

In: Human Genetics, Vol. 72, No. 2, 02.1986, p. 172-173.

Research output: Contribution to journalArticle

Covone, Angela E. ; Johnson, P. M. / Identification of trophoblast in chorionic villi biopsy samples. In: Human Genetics. 1986 ; Vol. 72, No. 2. pp. 172-173.
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