Identification of two new HLA-B alleles, HLA-B*0732 and HLA-B*5809, by sequence-based typing

E. Longhi, S. Frison, F. Poli, A. Espadas De Arias, C. Zanuso, E. Guizzardi, M. Scalamogna

Research output: Contribution to journalArticle

Abstract

Here, we have described the characterization of two novel human leukocyte antigen-B (HLA-B) alleles. The new alleles, HLA-B*0732 and HLA-B*5809, were identified in Italian Caucasian individuals. B*0732 differs from HLA-B*0708 by one nucleotidic change at position 412 (from G to A) in exon 3, leading to an amino acidic substitution from Asp (GAC) to Asn (AAC) at codon 114. The sequence of B*5809 is identical to that of HLA-B*5801, except for a point mutation at position 583 in exon 3, where a T is substituted by a C. This change leads to an amino acidic substitution from Tyr (TAC) to His (CAC) at codon 171.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalTissue Antigens
Volume63
Issue number3
DOIs
Publication statusPublished - Mar 2004

Keywords

  • HLA
  • SBT

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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