Abstract
We describe the isolation and characterization of two novel HLA-DRB1*11 alleles, officially named DRB1*1161 and 110404. These two new variants were both identified in two Caucasoid individuals. The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC>AAC) is responsible for an amino-acidic change from Asp to Asn. The exon 2 sequence of the second novel allele described here, DRB1*110404, differs from that of DRB1*110401 only at codon 34 where the nucleotidic change CAA>CAG gives rise to a silent mutation.
| Original language | English |
|---|---|
| Pages (from-to) | 237-239 |
| Number of pages | 3 |
| Journal | International Journal of Immunogenetics |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2007 |
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ASJC Scopus subject areas
- Genetics
- Immunology
- Molecular Biology
Cite this
Identification of two novel HLA-DRB1*11 alleles (DRB1*110404 and DRB1*1161) in two Italian cord blood units. / Longhi, E.; Frison, S.; Serafini, M.; Karpasitou, K.; Poli, F.
In: International Journal of Immunogenetics, Vol. 34, No. 4, 08.2007, p. 237-239.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of two novel HLA-DRB1*11 alleles (DRB1*110404 and DRB1*1161) in two Italian cord blood units
AU - Longhi, E.
AU - Frison, S.
AU - Serafini, M.
AU - Karpasitou, K.
AU - Poli, F.
PY - 2007/8
Y1 - 2007/8
N2 - We describe the isolation and characterization of two novel HLA-DRB1*11 alleles, officially named DRB1*1161 and 110404. These two new variants were both identified in two Caucasoid individuals. The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC>AAC) is responsible for an amino-acidic change from Asp to Asn. The exon 2 sequence of the second novel allele described here, DRB1*110404, differs from that of DRB1*110401 only at codon 34 where the nucleotidic change CAA>CAG gives rise to a silent mutation.
AB - We describe the isolation and characterization of two novel HLA-DRB1*11 alleles, officially named DRB1*1161 and 110404. These two new variants were both identified in two Caucasoid individuals. The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC>AAC) is responsible for an amino-acidic change from Asp to Asn. The exon 2 sequence of the second novel allele described here, DRB1*110404, differs from that of DRB1*110401 only at codon 34 where the nucleotidic change CAA>CAG gives rise to a silent mutation.
UR - http://www.scopus.com/inward/record.url?scp=34447320483&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447320483&partnerID=8YFLogxK
U2 - 10.1111/j.1744-313X.2007.00692.x
DO - 10.1111/j.1744-313X.2007.00692.x
M3 - Article
C2 - 17627757
AN - SCOPUS:34447320483
VL - 34
SP - 237
EP - 239
JO - International Journal of Immunogenetics
JF - International Journal of Immunogenetics
SN - 1744-3121
IS - 4
ER -