Identification of two novel HLA-DRB1*11 alleles (DRB1*110404 and DRB1*1161) in two Italian cord blood units

E. Longhi, S. Frison, M. Serafini, K. Karpasitou, F. Poli

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We describe the isolation and characterization of two novel HLA-DRB1*11 alleles, officially named DRB1*1161 and 110404. These two new variants were both identified in two Caucasoid individuals. The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC>AAC) is responsible for an amino-acidic change from Asp to Asn. The exon 2 sequence of the second novel allele described here, DRB1*110404, differs from that of DRB1*110401 only at codon 34 where the nucleotidic change CAA>CAG gives rise to a silent mutation.

Original languageEnglish
Pages (from-to)237-239
Number of pages3
JournalInternational Journal of Immunogenetics
Volume34
Issue number4
DOIs
Publication statusPublished - Aug 2007

Fingerprint

HLA-DRB1 Chains
Fetal Blood
Codon
Exons
Alleles
Viperidae
Nucleotides
Silent Mutation

ASJC Scopus subject areas

  • Genetics
  • Immunology
  • Molecular Biology

Cite this

Identification of two novel HLA-DRB1*11 alleles (DRB1*110404 and DRB1*1161) in two Italian cord blood units. / Longhi, E.; Frison, S.; Serafini, M.; Karpasitou, K.; Poli, F.

In: International Journal of Immunogenetics, Vol. 34, No. 4, 08.2007, p. 237-239.

Research output: Contribution to journalArticle

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