Identification, ultrastructure and classification of gut endocrine cells and related growths

E. Solcia, C. Capella, R. Buffa, R. Fiocca, B. Frigerio, L. Usellini

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Up to 14 endocrine cell types have been identified ultrastructurally and/or histochemically in the gastroenteric mucosa. Of these gastrin (G), somatostatin (D), glucagon (A), secretin (S), CCK (I), GIP (K) and neurotensin (N) cells have been confirmed cytochemically and are considered as fully established cell types. PP and GLI cells have also been identified cytochemically. EC cells, long known ultrastructurally and as 5HT producers, are now known to produce also substance P and enkephalin. P, D 1, X and ECL cells, although ultrastructurally defined still await functional identification. At present, a precise cytological classification of endocrine-like tumours of the gut is hardly feasible. For practical purposes it seems preferable to distinguish carcinoids, either argentaffin or non-argentaffin, from true endocrine tumours of the gut (essentially gastrinomas). Non-argentaffin carcinoids will encompass a cytologically heterogeneous group of tumours, easily subdivided on simple topographic grounds.

Original languageEnglish
Pages (from-to)37-49
Number of pages13
JournalInvestigative and Cell Pathology
Volume3
Issue number1
Publication statusPublished - 1980

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Enteroendocrine Cells
Carcinoid Tumor
Growth
Enterochromaffin-like Cells
Gastrinoma
Neoplasms
Neurotensin
Secretin
Endocrine Cells
Enkephalins
Gastrins
Substance P
Somatostatin
Glucagon
Mucous Membrane

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Identification, ultrastructure and classification of gut endocrine cells and related growths. / Solcia, E.; Capella, C.; Buffa, R.; Fiocca, R.; Frigerio, B.; Usellini, L.

In: Investigative and Cell Pathology, Vol. 3, No. 1, 1980, p. 37-49.

Research output: Contribution to journalArticle

Solcia, E. ; Capella, C. ; Buffa, R. ; Fiocca, R. ; Frigerio, B. ; Usellini, L. / Identification, ultrastructure and classification of gut endocrine cells and related growths. In: Investigative and Cell Pathology. 1980 ; Vol. 3, No. 1. pp. 37-49.
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