Identifying risk factors for cognitive issues in multiple sclerosis

Maria Pia Amato, Elio Prestipino, Angelo Bellinvia

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Introduction: Cognitive impairment (CI) in Multiple Sclerosis (MS) has progressively regained clinical and research interest and is currently recognized as a debilitating and burdensome problem for these patients. Studying risk and protecting factors that may influence the development and course of CI is currently an area of increasing interest, due to the potential for preventive strategies. Areas covered: In this narrative review the authors briefly addressed the physiopathologic basis, assessment and management of CI in MS and then focused on identifying modifiable and not modifiable risk factors for CI in MS, providing an overview of the current knowledge in the field and indicating avenues for future research. Expert opinion: Improving our understanding of potentially modifiable environmental and lifestyle risk factors or protective factors for CI is important in order to prompt preventive strategies and orient patient counselling and clinical management. To this aim, we need to enhance the current level of evidence linking lifestyle factors to cognition and evaluate some factors that were only preliminary addressed in research. Moreover, we need to explore the role of each factor into the subject cognitive outcome, next to the possible interactions between different environmental factors as well as between environmental and genetic factors.

Original languageEnglish
Pages (from-to)333-347
Number of pages15
JournalExpert Review of Neurotherapeutics
Volume19
Issue number4
DOIs
Publication statusPublished - Apr 3 2019

Fingerprint

Multiple Sclerosis
Life Style
Expert Testimony
Research
Cognition
Counseling
Cognitive Dysfunction

Keywords

  • cognitive assessment
  • cognitive impairment
  • Multiple sclerosis
  • protective factors
  • risk factors

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Cite this

Identifying risk factors for cognitive issues in multiple sclerosis. / Amato, Maria Pia; Prestipino, Elio; Bellinvia, Angelo.

In: Expert Review of Neurotherapeutics, Vol. 19, No. 4, 03.04.2019, p. 333-347.

Research output: Contribution to journalReview article

Amato, Maria Pia ; Prestipino, Elio ; Bellinvia, Angelo. / Identifying risk factors for cognitive issues in multiple sclerosis. In: Expert Review of Neurotherapeutics. 2019 ; Vol. 19, No. 4. pp. 333-347.
@article{68f300e56c794715b42f56220e3cd8e7,
title = "Identifying risk factors for cognitive issues in multiple sclerosis",
abstract = "Introduction: Cognitive impairment (CI) in Multiple Sclerosis (MS) has progressively regained clinical and research interest and is currently recognized as a debilitating and burdensome problem for these patients. Studying risk and protecting factors that may influence the development and course of CI is currently an area of increasing interest, due to the potential for preventive strategies. Areas covered: In this narrative review the authors briefly addressed the physiopathologic basis, assessment and management of CI in MS and then focused on identifying modifiable and not modifiable risk factors for CI in MS, providing an overview of the current knowledge in the field and indicating avenues for future research. Expert opinion: Improving our understanding of potentially modifiable environmental and lifestyle risk factors or protective factors for CI is important in order to prompt preventive strategies and orient patient counselling and clinical management. To this aim, we need to enhance the current level of evidence linking lifestyle factors to cognition and evaluate some factors that were only preliminary addressed in research. Moreover, we need to explore the role of each factor into the subject cognitive outcome, next to the possible interactions between different environmental factors as well as between environmental and genetic factors.",
keywords = "cognitive assessment, cognitive impairment, Multiple sclerosis, protective factors, risk factors",
author = "Amato, {Maria Pia} and Elio Prestipino and Angelo Bellinvia",
year = "2019",
month = "4",
day = "3",
doi = "10.1080/14737175.2019.1590199",
language = "English",
volume = "19",
pages = "333--347",
journal = "Expert Review of Neurotherapeutics",
issn = "1473-7175",
publisher = "Expert Reviews Ltd.",
number = "4",

}

TY - JOUR

T1 - Identifying risk factors for cognitive issues in multiple sclerosis

AU - Amato, Maria Pia

AU - Prestipino, Elio

AU - Bellinvia, Angelo

PY - 2019/4/3

Y1 - 2019/4/3

N2 - Introduction: Cognitive impairment (CI) in Multiple Sclerosis (MS) has progressively regained clinical and research interest and is currently recognized as a debilitating and burdensome problem for these patients. Studying risk and protecting factors that may influence the development and course of CI is currently an area of increasing interest, due to the potential for preventive strategies. Areas covered: In this narrative review the authors briefly addressed the physiopathologic basis, assessment and management of CI in MS and then focused on identifying modifiable and not modifiable risk factors for CI in MS, providing an overview of the current knowledge in the field and indicating avenues for future research. Expert opinion: Improving our understanding of potentially modifiable environmental and lifestyle risk factors or protective factors for CI is important in order to prompt preventive strategies and orient patient counselling and clinical management. To this aim, we need to enhance the current level of evidence linking lifestyle factors to cognition and evaluate some factors that were only preliminary addressed in research. Moreover, we need to explore the role of each factor into the subject cognitive outcome, next to the possible interactions between different environmental factors as well as between environmental and genetic factors.

AB - Introduction: Cognitive impairment (CI) in Multiple Sclerosis (MS) has progressively regained clinical and research interest and is currently recognized as a debilitating and burdensome problem for these patients. Studying risk and protecting factors that may influence the development and course of CI is currently an area of increasing interest, due to the potential for preventive strategies. Areas covered: In this narrative review the authors briefly addressed the physiopathologic basis, assessment and management of CI in MS and then focused on identifying modifiable and not modifiable risk factors for CI in MS, providing an overview of the current knowledge in the field and indicating avenues for future research. Expert opinion: Improving our understanding of potentially modifiable environmental and lifestyle risk factors or protective factors for CI is important in order to prompt preventive strategies and orient patient counselling and clinical management. To this aim, we need to enhance the current level of evidence linking lifestyle factors to cognition and evaluate some factors that were only preliminary addressed in research. Moreover, we need to explore the role of each factor into the subject cognitive outcome, next to the possible interactions between different environmental factors as well as between environmental and genetic factors.

KW - cognitive assessment

KW - cognitive impairment

KW - Multiple sclerosis

KW - protective factors

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=85064043951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064043951&partnerID=8YFLogxK

U2 - 10.1080/14737175.2019.1590199

DO - 10.1080/14737175.2019.1590199

M3 - Review article

C2 - 30829076

AN - SCOPUS:85064043951

VL - 19

SP - 333

EP - 347

JO - Expert Review of Neurotherapeutics

JF - Expert Review of Neurotherapeutics

SN - 1473-7175

IS - 4

ER -