IDH signalling pathway in cholangiocarcinoma: From biological rationale to therapeutic targeting

Massimiliano Salati, Francesco Caputo, Cinzia Baldessari, Barbara Galassi, Francesco Grossi, Massimo Dominici, Michele Ghidini

Research output: Contribution to journalReview articlepeer-review

Abstract

Biliary tract cancers are anatomically distinct and genetically diverse tumors, evenly characterized by poor response to standard treatments and a bleak outlook. The advent of comprehensive genomic profiling using next-generation sequencing has unveiled a plethora of potentially actionable aberrations, changing the view of biliary tract cancers from an “orphan” to a “target-rich” disease. Recently, mutations in isocitrate dehydrogenase genes (IDH1/2) and fusions of the fibroblast growth factor receptor have emerged as the most amenable to molecularly targeted inhibition, with several compounds actively investigated in advanced-phase clinical trials. Specifically, the IDH1 inhibitor ivosidenib has been the first targeted agent to show a survival benefit in a randomized phase III trial of cholangiocarcinoma patients harboring IDH1 mutations. In this review article, we will focus on the IDH1/IDH2 pathway, discussing the preclinical rationale of its targeting as well as the promises and challenges of the clinical development of IDH inhibitors in biliary tract cancers.

Original languageEnglish
Article number3310
Number of pages11
JournalCancers
Volume12
Issue number11
DOIs
Publication statusPublished - Nov 2020

Keywords

  • Biliary cancer
  • Cholangiocarcinoma
  • Gallbladder cancer
  • IDH
  • Ivosidenib
  • Precision medicine
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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