Idiopathic arterial calcification of infancy: Effectiveness of prostaglandin infusion for treatment of secondary hypertension refractory to conventional therapy: Case report

G. Ciana, F. Colonna, V. Forleo, F. Brizzi, A. Benettoni, U. De Vonderweid

Research output: Contribution to journalArticlepeer-review

Abstract

A premature baby had severe hypertension associated with idiopathic arterial calcification of infancy. Despite the fact that there was laboratory evidence of renin-mediated hypertension, the disease was refractory to specific renin antagonist and failed to respond to conventional medical treatment. Prostaglandin E1 (PGE1) infusion (dosage range 0.017-0.068 μg/kg/min) promptly controlled hypertension on two occasions. The drug was given for a total of 65 days and then stopped after the appearance of severe thrombocytopenia; other side effects included sporadic hyperthermia and irritability. Blood pressure was then stabilized satisfactory by a multiple- antihypertensive regimen. In the light of these findings, we believe that PGE1 infusion is a possible therapeutic alternative for babies with idiopathic arterial calcification complicated by severe hypertension refractory to conventional treatment.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalPediatric Cardiology
Volume18
Issue number1
DOIs
Publication statusPublished - 1997

Keywords

  • Hypertension
  • Idiopathic arterial calcification
  • Prostaglandins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

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