Idiopathic cerebrospinal fluid overproduction: Case-based review of the pathophysiological mechanism implied in the cerebrospinal fluid production

Gianluca Trevisi, Paolo Frassanito, Concezio di Rocco

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebrospinal fluid (CSF) overproduction results from either CSF infection or choroid plexus hypertrophy or tumor, with only a single idiopathic case described so far. We report a unique case of a male infant with Crouzon syndrome who presented with intracranial hypertension, caused by up to 4-fold increase in CSF daily production. Conditions related to CSF overproduction, namely central nervous system infections and choroid plexus hypertrophy or tumor, were ruled out by repeated magnetic resonance imaging and CSF samples. Medical therapy failed to reduce CSF production and the patient underwent several shunting procedures, cranial expansion, and endoscopic coagulation of the choroid plexus. This article thoroughly reviews pertinent literature on CSF production mechanisms and possible therapeutic implications.

Original languageEnglish
Pages (from-to)377-387
Number of pages11
JournalCroatian Medical Journal
Volume55
Issue number4
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Medicine(all)

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