Idiopathic chronic pancreatitis in children: MR cholangiopancreatography after secretin administration

Riccardo Manfredi, Vincenzina Lucidi, Benedetta Gui, M. Gabriella Brizi, Amorino Vecchioli, Giulia Maresca, Luigi Dall'Oglio, Guido Costamagna, Pasquale Marano

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Abstract

PURPOSE: To assess the accuracy of dynamic magnetic resonance (MR) cholangiopancreatography after secretin administration in detecting pancreatic duct abnormalities typical of early-onset idiopathic chronic pancreatitis in children with recurrent episodes of idiopathic acute pancreatitis. MATERIALS AND METHODS: Fifteen children (mean age, 11.3 years; range, 6-17 years) with at least three recurrent episodes of idiopathic acute pancreatitis prospectively underwent MR cholangiopancreatography before and after secretin administration. Image analysis included visualization of side branches, ductal narrowing, endoluminal filling defects, irregular ductal contour, cavities, and pancreas divisum. All patients underwent endoscopic retrograde cholangiopancreatography (ERCP). RESULTS: Dilated side branches were detected in three (20%) of 15 patients on MR cholangiopancreatograms obtained before secretin administration and in seven (47%) of 15 patients on images obtained after secretin administration. Ductal narrowing was detected in one (7%) of 15 patients on images obtained before secretin administration and in two (13%) of 15 patients on images obtained after secretin administration. Endoluminal filling defects in one (7%) of 15 patients were observed on MR cholangiopancreatograms obtained both before and after secretin administration. Irregular contour of the main pancreatic duct was present in four (27%) of 15 patients on MR cholangiopancreatograms obtained before secretin administration and in five (33%) of 15 patients on images obtained after secretin administration. Cavities and pancreas divisum were detected in one (7%) of 15 patients and in two (13%) of 15 patients, respectively, only on MR cholangiopancreatograms obtained after secretin administration. CONCLUSION: Secretin improves the sensitivity of MR cholangiopancreatography in diagnosing early-onset idiopathic chronic pancreatitis.

Original languageEnglish
Pages (from-to)675-682
Number of pages8
JournalRadiology
Volume224
Issue number3
Publication statusPublished - Sep 2002

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Keywords

  • Bile ducts, MR
  • Children, gastrointestinal system
  • Endoscopic retrograde cholangiopancreatography (ERCP)
  • Magnetic resonance (MR), cholangiopancreatography
  • Pancreatitis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Manfredi, R., Lucidi, V., Gui, B., Brizi, M. G., Vecchioli, A., Maresca, G., Dall'Oglio, L., Costamagna, G., & Marano, P. (2002). Idiopathic chronic pancreatitis in children: MR cholangiopancreatography after secretin administration. Radiology, 224(3), 675-682.