In a patient with primary hypoparathyroidism the disease ran for years with only generalized convulsions resistant to antiepileptic medication, and was later complicated by bilateral cataracts. Low serum calcium and elevated serum phosphorus, found on occasion of a grand mal status resistant to routine treatment and to intravenous barbiturates, revealed the correct diagnosis. The seizures were suppressed by normalizing the serum calcium levels. The pathophysiology of convulsive seizures during hypocalcemia is discussed, and the possibility is raised that antiepileptic drugs could have contributed to hypocalcemia through a vitamin D deficiency.
|Translated title of the contribution||Idiopathic hyperparathyroidism and epileptic seizures|
|Number of pages||11|
|Journal||Rivista di Neurologia|
|Publication status||Published - 1980|
ASJC Scopus subject areas
- Clinical Neurology