Idiopathic IgA nephropathy with segmental necrotizing lesions of the capillary wall

G. D'Amico, P. Napodano, F. Ferrario, M. P. Rastaldi, G. Arrigo

Research output: Contribution to journalArticlepeer-review


Background. Segmental glomerular necrosis has been described in the biopsy material in a minority of patients with idiopathic IgA nephropathy in the oldest studies on this disease, but this marker of active capillaritis has received little attention in the subsequent literature, and its significance and relevance for the clinical outcome is still unknown. Methods. Thirty-five out of 340 patients (10.3%) biopsied in our division at the San Carlo Hospital since 1974 showed active segmental necrotizing lesions. The morphological features and the natural history of this group of patients were compared with those of a control group of 229 patients who had comparable serum creatinine and extent of glomerular sclerosis, but who lacked active segmental necrosis. Results. Patients with the necrotic variant showed a significantly more marked extracapillary proliferation and interstitial accumulation of monocytes and T lymphocytes and, in the segmental areas of necrotizing and extracapillary lesions, infiltration of monocytes, deposition of fibrinogen, and expression of the adhesion molecule vascular cell adhesion molecule-1. No difference was found in the presenting clinical syndrome. The clinical course was frequently characterized by acute flareups, and the progression to end-stage renal failure was more frequent, although actuarial renal survival was not significantly worse (P = 0.07). The aggressive treatment with steroids and cyclophosphamide, carried out in 20 of the 35 patients, has probably been beneficial, justifying the multicenter controlled trial that recently has been initiated. Conclusions. Vasculitic lesions of the glomerular capillaries, with histologic and immunohistological features similar to those of Henoch-Schönlein purpura and antineutrophil cytoplasmic antibody-positive renal vasculitis, were found in 10% of patients with idiopathic IgAN. Clinical features at presentation did not differ from those of the other patients with IgAN, and despite of the more frequent occurrences of recurrent acute flareups, rapid progression to end-stage renal failure was a rare phenomenon, even in untreated patients.

Original languageEnglish
Pages (from-to)682-692
Number of pages11
JournalKidney International
Issue number2
Publication statusPublished - 2001


  • Active capillaritis
  • Berger disease
  • Endothelium injury
  • Glomerulonephritis
  • Necrosis
  • Vasculitic damage

ASJC Scopus subject areas

  • Nephrology


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