Idiopathic inflammatory myopathies evaluated by near-infrared spectroscopy

Pietro Caliandro, Massimiliano Mirabella, Luca Padua, Chiara Simbolotti, Chiara De Fino, Chiara Iacovelli, Cristina Sancricca, Paolo M. Rossini

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: In this study we evaluated whether near-infrared spectroscopy (NIRS) can determine the metabolic patterns of dermatomyositis (DM), polymyositis (PM), and inclusion-body myositis (IBM). Methods: We enrolled 10 consecutive patients affected by DM, 11 by PM, and 9 by IBM, and 3 groups of healthy controls. We measured changes in oxygenated and deoxygenated hemoglobin/myoglobin in the extensor digitorum communis during venous and arterial occlusion testing (VOT) and post-occlusion hyperemia. Results: DM showed lower oxygen consumption (P=0.04) during VOT and reduced oxygen supply after VOT (P=0.04) compared with controls. IBM patients showed higher oxygen consumption (P=0.04) during VOT and higher oxygen supply after VOT (P=0.03) than controls. DM patients showed reduced oxidative metabolism compared with IBM (P=0.001), and an impaired ability to supply oxygen compared with PM (P=0.03) and IBM (P=0.001) patients. Conclusions: NIRS differentiated samples of DM and IBM patients from controls, but it could not distinguish PM patients from a sample of healthy subjects.

Original languageEnglish
Pages (from-to)830-837
Number of pages8
JournalMuscle and Nerve
Volume51
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Dermatomyositis
  • Inclusion-body myositis
  • Inflammatory myopathy
  • NIRS
  • Polymyositis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology
  • Medicine(all)

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