Idiopathic inflammatory myopathies evaluated by near-infrared spectroscopy

Pietro Caliandro; Massimiliano Mirabella; Luca Padua; Chiara Simbolotti; Chiara De Fino; Chiara Iacovelli; Cristina Sancricca; Paolo M. Rossini

doi:10.1002/mus.24476

Idiopathic inflammatory myopathies evaluated by near-infrared spectroscopy

Pietro Caliandro, Massimiliano Mirabella, Luca Padua, Chiara Simbolotti, Chiara De Fino, Chiara Iacovelli, Cristina Sancricca, Paolo M. Rossini

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: In this study we evaluated whether near-infrared spectroscopy (NIRS) can determine the metabolic patterns of dermatomyositis (DM), polymyositis (PM), and inclusion-body myositis (IBM). Methods: We enrolled 10 consecutive patients affected by DM, 11 by PM, and 9 by IBM, and 3 groups of healthy controls. We measured changes in oxygenated and deoxygenated hemoglobin/myoglobin in the extensor digitorum communis during venous and arterial occlusion testing (VOT) and post-occlusion hyperemia. Results: DM showed lower oxygen consumption (P=0.04) during VOT and reduced oxygen supply after VOT (P=0.04) compared with controls. IBM patients showed higher oxygen consumption (P=0.04) during VOT and higher oxygen supply after VOT (P=0.03) than controls. DM patients showed reduced oxidative metabolism compared with IBM (P=0.001), and an impaired ability to supply oxygen compared with PM (P=0.03) and IBM (P=0.001) patients. Conclusions: NIRS differentiated samples of DM and IBM patients from controls, but it could not distinguish PM patients from a sample of healthy subjects.

Original language	English
Pages (from-to)	830-837
Number of pages	8
Journal	Muscle and Nerve
Volume	51
Issue number	6
DOIs	https://doi.org/10.1002/mus.24476
Publication status	Published - Jun 1 2015

Keywords

Dermatomyositis
Inclusion-body myositis
Inflammatory myopathy
NIRS
Polymyositis

ASJC Scopus subject areas

Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)
Physiology
Medicine(all)

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@article{89535820b20140569dec69d06a3b4aa0,

title = "Idiopathic inflammatory myopathies evaluated by near-infrared spectroscopy",

abstract = "Introduction: In this study we evaluated whether near-infrared spectroscopy (NIRS) can determine the metabolic patterns of dermatomyositis (DM), polymyositis (PM), and inclusion-body myositis (IBM). Methods: We enrolled 10 consecutive patients affected by DM, 11 by PM, and 9 by IBM, and 3 groups of healthy controls. We measured changes in oxygenated and deoxygenated hemoglobin/myoglobin in the extensor digitorum communis during venous and arterial occlusion testing (VOT) and post-occlusion hyperemia. Results: DM showed lower oxygen consumption (P=0.04) during VOT and reduced oxygen supply after VOT (P=0.04) compared with controls. IBM patients showed higher oxygen consumption (P=0.04) during VOT and higher oxygen supply after VOT (P=0.03) than controls. DM patients showed reduced oxidative metabolism compared with IBM (P=0.001), and an impaired ability to supply oxygen compared with PM (P=0.03) and IBM (P=0.001) patients. Conclusions: NIRS differentiated samples of DM and IBM patients from controls, but it could not distinguish PM patients from a sample of healthy subjects.",

keywords = "Dermatomyositis, Inclusion-body myositis, Inflammatory myopathy, NIRS, Polymyositis",

author = "Pietro Caliandro and Massimiliano Mirabella and Luca Padua and Chiara Simbolotti and Fino, {Chiara De} and Chiara Iacovelli and Cristina Sancricca and Rossini, {Paolo M.}",

year = "2015",

month = jun,

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doi = "10.1002/mus.24476",

language = "English",

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T1 - Idiopathic inflammatory myopathies evaluated by near-infrared spectroscopy

AU - Caliandro, Pietro

AU - Mirabella, Massimiliano

AU - Padua, Luca

AU - Simbolotti, Chiara

AU - Fino, Chiara De

AU - Iacovelli, Chiara

AU - Sancricca, Cristina

AU - Rossini, Paolo M.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Introduction: In this study we evaluated whether near-infrared spectroscopy (NIRS) can determine the metabolic patterns of dermatomyositis (DM), polymyositis (PM), and inclusion-body myositis (IBM). Methods: We enrolled 10 consecutive patients affected by DM, 11 by PM, and 9 by IBM, and 3 groups of healthy controls. We measured changes in oxygenated and deoxygenated hemoglobin/myoglobin in the extensor digitorum communis during venous and arterial occlusion testing (VOT) and post-occlusion hyperemia. Results: DM showed lower oxygen consumption (P=0.04) during VOT and reduced oxygen supply after VOT (P=0.04) compared with controls. IBM patients showed higher oxygen consumption (P=0.04) during VOT and higher oxygen supply after VOT (P=0.03) than controls. DM patients showed reduced oxidative metabolism compared with IBM (P=0.001), and an impaired ability to supply oxygen compared with PM (P=0.03) and IBM (P=0.001) patients. Conclusions: NIRS differentiated samples of DM and IBM patients from controls, but it could not distinguish PM patients from a sample of healthy subjects.

AB - Introduction: In this study we evaluated whether near-infrared spectroscopy (NIRS) can determine the metabolic patterns of dermatomyositis (DM), polymyositis (PM), and inclusion-body myositis (IBM). Methods: We enrolled 10 consecutive patients affected by DM, 11 by PM, and 9 by IBM, and 3 groups of healthy controls. We measured changes in oxygenated and deoxygenated hemoglobin/myoglobin in the extensor digitorum communis during venous and arterial occlusion testing (VOT) and post-occlusion hyperemia. Results: DM showed lower oxygen consumption (P=0.04) during VOT and reduced oxygen supply after VOT (P=0.04) compared with controls. IBM patients showed higher oxygen consumption (P=0.04) during VOT and higher oxygen supply after VOT (P=0.03) than controls. DM patients showed reduced oxidative metabolism compared with IBM (P=0.001), and an impaired ability to supply oxygen compared with PM (P=0.03) and IBM (P=0.001) patients. Conclusions: NIRS differentiated samples of DM and IBM patients from controls, but it could not distinguish PM patients from a sample of healthy subjects.

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KW - NIRS

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