Idiopathic infratentorial superficial siderosis of the central nervous system: case report and review of literature

Andrea Stabile, Vincenzo Di Lazzaro, Cesare Colosimo, Fabrizio Piazza, Carlo Ferrarese, Jacopo C. DiFrancesco

Research output: Contribution to journalArticle

Abstract

The superficial siderosis (SS) of the central nervous system (CNS) is a rare condition characterized by a wide range of neurological manifestations directly linked to an acquired iron-mediated neurodegeneration. First described more than 100 years ago, only recently SS has been divided into two distinct entities, according to the distribution of iron deposition in the CNS: cortical superficial siderosis (cSS) and infratentorial superficial siderosis (iSS). Here we describe an adult case of iSS, with detailed clinical and radiological features. Moreover, we extensively review the literature of SS, particularly focusing on the pathogenesis, clinical-radiological classification, diagnostic algorithm and treatment options of this rare condition.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalNeurologia i Neurochirurgia Polska
Volume52
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Brain Magnetic Resonance Imaging (MRI)
  • Cerebral amyloid angiopathy
  • Hemosiderin
  • Superficial siderosis
  • Susceptibility weighted imaging

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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