Abstract
We report a case of idiopathic intracranial hypertension (IIH) (pseudotumor cerebri) following treatment with recombinant growth hormone (rhGH). A 9-year-old girl, treated for GH deficiency, developed bitemporal worsening headache, diplopia, intermittent exotropia and visual loss 3 months after starting rhGH. Ocular fundus examination revealed bilateral papilloedema and a MRI scan ruled out intracranial disease (including venous sinus thrombosis), leading to diagnosis of IIH. rhGH was discontinued and acetazolamide therapy was initiated up to 30 mg/kg/die dose without clinical improvement and with mild metabolic acidosis. We reduced acetazolamide to 20 mg/kg/die and added dexamethasone ev (0,4 mg/kg/die) with dramatic answer already after 1 day, then confirmed by fundus oculi and visual evocated potential. We suggest the use of corticosteroids in IIH when acetazolamide is inefficient or intolerable.
| Original language | Italian |
|---|---|
| Pages (from-to) | 460-461 |
| Number of pages | 2 |
| Journal | Medico e Bambino |
| Volume | 26 |
| Issue number | 7 |
| Publication status | Published - Sep 30 2007 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Ipertensione endocranica idiopatica (pseudotumor cerebri) in una bambina in terapia con ormone della crescita. / Tornese, G.; Patarino, F.; Pensiero, S.; Parentin, F.; Faleschini, E.; Tonini, G.; Marchetti, F.
In: Medico e Bambino, Vol. 26, No. 7, 30.09.2007, p. 460-461.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ipertensione endocranica idiopatica (pseudotumor cerebri) in una bambina in terapia con ormone della crescita
AU - Tornese, G.
AU - Patarino, F.
AU - Pensiero, S.
AU - Parentin, F.
AU - Faleschini, E.
AU - Tonini, G.
AU - Marchetti, F.
PY - 2007/9/30
Y1 - 2007/9/30
N2 - We report a case of idiopathic intracranial hypertension (IIH) (pseudotumor cerebri) following treatment with recombinant growth hormone (rhGH). A 9-year-old girl, treated for GH deficiency, developed bitemporal worsening headache, diplopia, intermittent exotropia and visual loss 3 months after starting rhGH. Ocular fundus examination revealed bilateral papilloedema and a MRI scan ruled out intracranial disease (including venous sinus thrombosis), leading to diagnosis of IIH. rhGH was discontinued and acetazolamide therapy was initiated up to 30 mg/kg/die dose without clinical improvement and with mild metabolic acidosis. We reduced acetazolamide to 20 mg/kg/die and added dexamethasone ev (0,4 mg/kg/die) with dramatic answer already after 1 day, then confirmed by fundus oculi and visual evocated potential. We suggest the use of corticosteroids in IIH when acetazolamide is inefficient or intolerable.
AB - We report a case of idiopathic intracranial hypertension (IIH) (pseudotumor cerebri) following treatment with recombinant growth hormone (rhGH). A 9-year-old girl, treated for GH deficiency, developed bitemporal worsening headache, diplopia, intermittent exotropia and visual loss 3 months after starting rhGH. Ocular fundus examination revealed bilateral papilloedema and a MRI scan ruled out intracranial disease (including venous sinus thrombosis), leading to diagnosis of IIH. rhGH was discontinued and acetazolamide therapy was initiated up to 30 mg/kg/die dose without clinical improvement and with mild metabolic acidosis. We reduced acetazolamide to 20 mg/kg/die and added dexamethasone ev (0,4 mg/kg/die) with dramatic answer already after 1 day, then confirmed by fundus oculi and visual evocated potential. We suggest the use of corticosteroids in IIH when acetazolamide is inefficient or intolerable.
KW - Acetazolamide
KW - Corticosteroids
KW - Idiopathic intracranial hypertension
KW - rhGH
UR - http://www.scopus.com/inward/record.url?scp=35348821782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35348821782&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:35348821782
VL - 26
SP - 460
EP - 461
JO - Medico e Bambino
JF - Medico e Bambino
SN - 1591-3090
IS - 7
ER -