Ipertensione endocranica idiopatica (pseudotumor cerebri) in una bambina in terapia con ormone della crescita

Translated title of the contribution: Idiopathic intracranial hypertension (pseudotumor cerebri) in a girl receiving growth hormone treatment

G. Tornese, F. Patarino, S. Pensiero, F. Parentin, E. Faleschini, G. Tonini, F. Marchetti

Research output: Contribution to journalArticle

Abstract

We report a case of idiopathic intracranial hypertension (IIH) (pseudotumor cerebri) following treatment with recombinant growth hormone (rhGH). A 9-year-old girl, treated for GH deficiency, developed bitemporal worsening headache, diplopia, intermittent exotropia and visual loss 3 months after starting rhGH. Ocular fundus examination revealed bilateral papilloedema and a MRI scan ruled out intracranial disease (including venous sinus thrombosis), leading to diagnosis of IIH. rhGH was discontinued and acetazolamide therapy was initiated up to 30 mg/kg/die dose without clinical improvement and with mild metabolic acidosis. We reduced acetazolamide to 20 mg/kg/die and added dexamethasone ev (0,4 mg/kg/die) with dramatic answer already after 1 day, then confirmed by fundus oculi and visual evocated potential. We suggest the use of corticosteroids in IIH when acetazolamide is inefficient or intolerable.

Original languageItalian
Pages (from-to)460-461
Number of pages2
JournalMedico e Bambino
Volume26
Issue number7
Publication statusPublished - Sep 30 2007

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Pseudotumor Cerebri
Acetazolamide
Growth Hormone
Fundus Oculi
Intracranial Sinus Thrombosis
Exotropia
Papilledema
Diplopia
Therapeutics
Acidosis
Venous Thrombosis
Dexamethasone
Headache
Adrenal Cortex Hormones
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Ipertensione endocranica idiopatica (pseudotumor cerebri) in una bambina in terapia con ormone della crescita. / Tornese, G.; Patarino, F.; Pensiero, S.; Parentin, F.; Faleschini, E.; Tonini, G.; Marchetti, F.

In: Medico e Bambino, Vol. 26, No. 7, 30.09.2007, p. 460-461.

Research output: Contribution to journalArticle

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