Idiopathic late-onset absence status epilepticus: A case report with an electroclinical 14 years follow-up

Stefano Pro, Edoardo Vicenzini, Franco Randi, Patrizia Pulitano, Oriano Mecarelli

Research output: Contribution to journalArticlepeer-review


Late-onset absence status epilepticus (ASE) may be observed in adult and elderly patients as a late complication of idiopathic generalized epilepsy or de novo, usually related to benzodiazepines withdrawal, alcohol intoxication or psychotropic drugs initiation, but without history of epilepsy. EEG may be highly heterogeneous, varying from the 3 to 3.5 Hz spike-wave discharges typical of idiopathic generalized epilepsy to asymmetric irregular sharp and slow wave complexes. We report the clinical and neurophysiologic 14 years follow-up of a now 86 years-old woman, in whom we observed - at the age of 72 - an idiopathic late-onset ASE, with a good clinical response to lamotrigine monotherapy, but with the persistence over years of the same interictal 3-3.5 Hz spike-wave epileptic activity at EEG. This case is singular because, with the available long follow-up, indicates that idiopathic generalized epilepsy may also occur in the elderly, with a late-onset ASE presentation. In this condition, it is particularly important to underline the essential role of EEG (urgent and ambulatory) for the diagnosis, management and monitoring of the disease.

Original languageEnglish
Pages (from-to)655-658
Number of pages4
Issue number8
Publication statusPublished - Oct 2011


  • Ambulatory EEG
  • Elderly epilepsy
  • Late-onset absence status epilepticus
  • Non-convulsive status epilepticus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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