Idiopathic nonspecific interstitial pneumonia

An interstitial lung disease associated with autoimmune disorders?

M. Romagnoli, C. Nannini, S. Piciucchi, F. Girelli, C. Gurioli, G. Casoni, C. Ravaglia, S. Tomassetti, Ch Gurioli, G. Gavelli, A. Carloni, A. Dubini, F. Cantini, M. Chilosi, V. Poletti

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Recent evidence suggests that idiopathic nonspecific interstitial pneumonia (iNSIP) is a distinct clinical entity amongst other idiopathic interstitial pneumonias, and some data seem to suggest a possible pathogenetic role of autoimmunity. The aim of the present study was to assess if iNSIP might represent an early lung manifestation of an autoimmune disease. After initial review of cases found in the medical records database by searching for the term "NSIP" (n=63), 37 iNSIP cases were identified, and were re-evaluated using a dynamic integrated multidisciplinary approach. 27 cases with iNSIP were selected for the study. Mean ± SD age at first respiratory symptom was 54.2 ± 8 yrs, 70% were females, and 59% were never-smokers. At follow-up (mean ± SD 59.7 ± 29 months, range 12-138 months), autoimmune diseases occurred in 14 (52%) patients, with seven (26%) cases of autoimmune thyroiditis, six (22%) of undifferentiated connective tissue disease and three (11%) of connective tissue disease. Patients developing autoimmune diseases were older and more frequently never-smoking females. In >50% of patients diagnosed with iNSIP, evidence of autoimmune diseases develops within 2 yrs, suggesting a probable link between the clinical entity of iNSIP and autoimmune disorders. Copyright

Original languageEnglish
Pages (from-to)384-391
Number of pages8
JournalEuropean Respiratory Journal
Volume38
Issue number2
DOIs
Publication statusPublished - Aug 1 2011

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Idiopathic Interstitial Pneumonias
Interstitial Lung Diseases
Autoimmune Diseases
Connective Tissue Diseases
Autoimmune Thyroiditis
Autoimmunity
Medical Records
Smoking
Databases
Lung

Keywords

  • Autoimmune disease
  • Connective tissue disease
  • Idiopathic interstitial pneumonia
  • Lung
  • Thyroiditis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Romagnoli, M., Nannini, C., Piciucchi, S., Girelli, F., Gurioli, C., Casoni, G., ... Poletti, V. (2011). Idiopathic nonspecific interstitial pneumonia: An interstitial lung disease associated with autoimmune disorders? European Respiratory Journal, 38(2), 384-391. https://doi.org/10.1183/09031936.00094910

Idiopathic nonspecific interstitial pneumonia : An interstitial lung disease associated with autoimmune disorders? / Romagnoli, M.; Nannini, C.; Piciucchi, S.; Girelli, F.; Gurioli, C.; Casoni, G.; Ravaglia, C.; Tomassetti, S.; Gurioli, Ch; Gavelli, G.; Carloni, A.; Dubini, A.; Cantini, F.; Chilosi, M.; Poletti, V.

In: European Respiratory Journal, Vol. 38, No. 2, 01.08.2011, p. 384-391.

Research output: Contribution to journalArticle

Romagnoli, M, Nannini, C, Piciucchi, S, Girelli, F, Gurioli, C, Casoni, G, Ravaglia, C, Tomassetti, S, Gurioli, C, Gavelli, G, Carloni, A, Dubini, A, Cantini, F, Chilosi, M & Poletti, V 2011, 'Idiopathic nonspecific interstitial pneumonia: An interstitial lung disease associated with autoimmune disorders?', European Respiratory Journal, vol. 38, no. 2, pp. 384-391. https://doi.org/10.1183/09031936.00094910
Romagnoli, M. ; Nannini, C. ; Piciucchi, S. ; Girelli, F. ; Gurioli, C. ; Casoni, G. ; Ravaglia, C. ; Tomassetti, S. ; Gurioli, Ch ; Gavelli, G. ; Carloni, A. ; Dubini, A. ; Cantini, F. ; Chilosi, M. ; Poletti, V. / Idiopathic nonspecific interstitial pneumonia : An interstitial lung disease associated with autoimmune disorders?. In: European Respiratory Journal. 2011 ; Vol. 38, No. 2. pp. 384-391.
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