Abstract
Recent evidence suggests that idiopathic nonspecific interstitial pneumonia (iNSIP) is a distinct clinical entity amongst other idiopathic interstitial pneumonias, and some data seem to suggest a possible pathogenetic role of autoimmunity. The aim of the present study was to assess if iNSIP might represent an early lung manifestation of an autoimmune disease. After initial review of cases found in the medical records database by searching for the term "NSIP" (n=63), 37 iNSIP cases were identified, and were re-evaluated using a dynamic integrated multidisciplinary approach. 27 cases with iNSIP were selected for the study. Mean ± SD age at first respiratory symptom was 54.2 ± 8 yrs, 70% were females, and 59% were never-smokers. At follow-up (mean ± SD 59.7 ± 29 months, range 12-138 months), autoimmune diseases occurred in 14 (52%) patients, with seven (26%) cases of autoimmune thyroiditis, six (22%) of undifferentiated connective tissue disease and three (11%) of connective tissue disease. Patients developing autoimmune diseases were older and more frequently never-smoking females. In >50% of patients diagnosed with iNSIP, evidence of autoimmune diseases develops within 2 yrs, suggesting a probable link between the clinical entity of iNSIP and autoimmune disorders. Copyright
| Original language | English |
|---|---|
| Pages (from-to) | 384-391 |
| Number of pages | 8 |
| Journal | European Respiratory Journal |
| Volume | 38 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 1 2011 |
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Keywords
- Autoimmune disease
- Connective tissue disease
- Idiopathic interstitial pneumonia
- Lung
- Thyroiditis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Idiopathic nonspecific interstitial pneumonia : An interstitial lung disease associated with autoimmune disorders? / Romagnoli, M.; Nannini, C.; Piciucchi, S.; Girelli, F.; Gurioli, C.; Casoni, G.; Ravaglia, C.; Tomassetti, S.; Gurioli, Ch; Gavelli, G.; Carloni, A.; Dubini, A.; Cantini, F.; Chilosi, M.; Poletti, V.
In: European Respiratory Journal, Vol. 38, No. 2, 01.08.2011, p. 384-391.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Idiopathic nonspecific interstitial pneumonia
T2 - An interstitial lung disease associated with autoimmune disorders?
AU - Romagnoli, M.
AU - Nannini, C.
AU - Piciucchi, S.
AU - Girelli, F.
AU - Gurioli, C.
AU - Casoni, G.
AU - Ravaglia, C.
AU - Tomassetti, S.
AU - Gurioli, Ch
AU - Gavelli, G.
AU - Carloni, A.
AU - Dubini, A.
AU - Cantini, F.
AU - Chilosi, M.
AU - Poletti, V.
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Recent evidence suggests that idiopathic nonspecific interstitial pneumonia (iNSIP) is a distinct clinical entity amongst other idiopathic interstitial pneumonias, and some data seem to suggest a possible pathogenetic role of autoimmunity. The aim of the present study was to assess if iNSIP might represent an early lung manifestation of an autoimmune disease. After initial review of cases found in the medical records database by searching for the term "NSIP" (n=63), 37 iNSIP cases were identified, and were re-evaluated using a dynamic integrated multidisciplinary approach. 27 cases with iNSIP were selected for the study. Mean ± SD age at first respiratory symptom was 54.2 ± 8 yrs, 70% were females, and 59% were never-smokers. At follow-up (mean ± SD 59.7 ± 29 months, range 12-138 months), autoimmune diseases occurred in 14 (52%) patients, with seven (26%) cases of autoimmune thyroiditis, six (22%) of undifferentiated connective tissue disease and three (11%) of connective tissue disease. Patients developing autoimmune diseases were older and more frequently never-smoking females. In >50% of patients diagnosed with iNSIP, evidence of autoimmune diseases develops within 2 yrs, suggesting a probable link between the clinical entity of iNSIP and autoimmune disorders. Copyright
AB - Recent evidence suggests that idiopathic nonspecific interstitial pneumonia (iNSIP) is a distinct clinical entity amongst other idiopathic interstitial pneumonias, and some data seem to suggest a possible pathogenetic role of autoimmunity. The aim of the present study was to assess if iNSIP might represent an early lung manifestation of an autoimmune disease. After initial review of cases found in the medical records database by searching for the term "NSIP" (n=63), 37 iNSIP cases were identified, and were re-evaluated using a dynamic integrated multidisciplinary approach. 27 cases with iNSIP were selected for the study. Mean ± SD age at first respiratory symptom was 54.2 ± 8 yrs, 70% were females, and 59% were never-smokers. At follow-up (mean ± SD 59.7 ± 29 months, range 12-138 months), autoimmune diseases occurred in 14 (52%) patients, with seven (26%) cases of autoimmune thyroiditis, six (22%) of undifferentiated connective tissue disease and three (11%) of connective tissue disease. Patients developing autoimmune diseases were older and more frequently never-smoking females. In >50% of patients diagnosed with iNSIP, evidence of autoimmune diseases develops within 2 yrs, suggesting a probable link between the clinical entity of iNSIP and autoimmune disorders. Copyright
KW - Autoimmune disease
KW - Connective tissue disease
KW - Idiopathic interstitial pneumonia
KW - Lung
KW - Thyroiditis
UR - http://www.scopus.com/inward/record.url?scp=80051538319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051538319&partnerID=8YFLogxK
U2 - 10.1183/09031936.00094910
DO - 10.1183/09031936.00094910
M3 - Article
VL - 38
SP - 384
EP - 391
JO - European Journal of Respiratory Diseases
JF - European Journal of Respiratory Diseases
SN - 0903-1936
IS - 2
ER -