Idiopathic pinealitis

Case report

Demetrios C. Nikas, Umberto De Girolami, Amir A. Zamani, Geraldine S. Pinkus, Lorenzo Bello, Matthias Kirsch, Peter Mc L Black

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This 63-year-old man presented with complaints of 'having a feeling of falling backward' over a 3-month period. Results of his general physical examination, laboratory studies, and neurological examination were unremarkable. A magnetic resonance image revealed a 1.8 x 1.4 x 1.2-cm enhancing mass in the posterior third ventricle just above the corpora quadrigemina. The pineal gland was found to be diffusely enlarged at operation and separable from the posterior thalamus and was totally resected. The patient had an uneventful postoperative course but continues to be somewhat confused. The lesion consisted of a remarkable chronic inflammatory cell infiltrate permeating the pineal lobules and was composed of T and B lymphocytes, macrophages, eosinophils, and mast cells. Immunoperoxidase studies did not demonstrate Langerhans cells, and a search for microorganisms was unrevealing. There was no evidence of neoplasia; results of immunostaining for germ cell markers and other tumor-associated antigens were negative.

Original languageEnglish
Pages (from-to)330-334
Number of pages5
JournalJournal of Neurosurgery
Volume91
Issue number2
Publication statusPublished - Aug 1999

Fingerprint

Tectum Mesencephali
Accidental Falls
Third Ventricle
Pineal Gland
Langerhans Cells
Neurologic Examination
Neoplasm Antigens
Thalamus
Eosinophils
Mast Cells
Germ Cells
Physical Examination
Emotions
B-Lymphocytes
Magnetic Resonance Spectroscopy
Macrophages
T-Lymphocytes
Neoplasms

Keywords

  • Idiopathic pinealitis
  • Pineal gland
  • Pineal inflammation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Nikas, D. C., De Girolami, U., Zamani, A. A., Pinkus, G. S., Bello, L., Kirsch, M., & Black, P. M. L. (1999). Idiopathic pinealitis: Case report. Journal of Neurosurgery, 91(2), 330-334.

Idiopathic pinealitis : Case report. / Nikas, Demetrios C.; De Girolami, Umberto; Zamani, Amir A.; Pinkus, Geraldine S.; Bello, Lorenzo; Kirsch, Matthias; Black, Peter Mc L.

In: Journal of Neurosurgery, Vol. 91, No. 2, 08.1999, p. 330-334.

Research output: Contribution to journalArticle

Nikas, DC, De Girolami, U, Zamani, AA, Pinkus, GS, Bello, L, Kirsch, M & Black, PML 1999, 'Idiopathic pinealitis: Case report', Journal of Neurosurgery, vol. 91, no. 2, pp. 330-334.
Nikas DC, De Girolami U, Zamani AA, Pinkus GS, Bello L, Kirsch M et al. Idiopathic pinealitis: Case report. Journal of Neurosurgery. 1999 Aug;91(2):330-334.
Nikas, Demetrios C. ; De Girolami, Umberto ; Zamani, Amir A. ; Pinkus, Geraldine S. ; Bello, Lorenzo ; Kirsch, Matthias ; Black, Peter Mc L. / Idiopathic pinealitis : Case report. In: Journal of Neurosurgery. 1999 ; Vol. 91, No. 2. pp. 330-334.
@article{2b38f96cdc354abba07508af53167bab,
title = "Idiopathic pinealitis: Case report",
abstract = "This 63-year-old man presented with complaints of 'having a feeling of falling backward' over a 3-month period. Results of his general physical examination, laboratory studies, and neurological examination were unremarkable. A magnetic resonance image revealed a 1.8 x 1.4 x 1.2-cm enhancing mass in the posterior third ventricle just above the corpora quadrigemina. The pineal gland was found to be diffusely enlarged at operation and separable from the posterior thalamus and was totally resected. The patient had an uneventful postoperative course but continues to be somewhat confused. The lesion consisted of a remarkable chronic inflammatory cell infiltrate permeating the pineal lobules and was composed of T and B lymphocytes, macrophages, eosinophils, and mast cells. Immunoperoxidase studies did not demonstrate Langerhans cells, and a search for microorganisms was unrevealing. There was no evidence of neoplasia; results of immunostaining for germ cell markers and other tumor-associated antigens were negative.",
keywords = "Idiopathic pinealitis, Pineal gland, Pineal inflammation",
author = "Nikas, {Demetrios C.} and {De Girolami}, Umberto and Zamani, {Amir A.} and Pinkus, {Geraldine S.} and Lorenzo Bello and Matthias Kirsch and Black, {Peter Mc L}",
year = "1999",
month = "8",
language = "English",
volume = "91",
pages = "330--334",
journal = "Journal of Neurosurgery",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "2",

}

TY - JOUR

T1 - Idiopathic pinealitis

T2 - Case report

AU - Nikas, Demetrios C.

AU - De Girolami, Umberto

AU - Zamani, Amir A.

AU - Pinkus, Geraldine S.

AU - Bello, Lorenzo

AU - Kirsch, Matthias

AU - Black, Peter Mc L

PY - 1999/8

Y1 - 1999/8

N2 - This 63-year-old man presented with complaints of 'having a feeling of falling backward' over a 3-month period. Results of his general physical examination, laboratory studies, and neurological examination were unremarkable. A magnetic resonance image revealed a 1.8 x 1.4 x 1.2-cm enhancing mass in the posterior third ventricle just above the corpora quadrigemina. The pineal gland was found to be diffusely enlarged at operation and separable from the posterior thalamus and was totally resected. The patient had an uneventful postoperative course but continues to be somewhat confused. The lesion consisted of a remarkable chronic inflammatory cell infiltrate permeating the pineal lobules and was composed of T and B lymphocytes, macrophages, eosinophils, and mast cells. Immunoperoxidase studies did not demonstrate Langerhans cells, and a search for microorganisms was unrevealing. There was no evidence of neoplasia; results of immunostaining for germ cell markers and other tumor-associated antigens were negative.

AB - This 63-year-old man presented with complaints of 'having a feeling of falling backward' over a 3-month period. Results of his general physical examination, laboratory studies, and neurological examination were unremarkable. A magnetic resonance image revealed a 1.8 x 1.4 x 1.2-cm enhancing mass in the posterior third ventricle just above the corpora quadrigemina. The pineal gland was found to be diffusely enlarged at operation and separable from the posterior thalamus and was totally resected. The patient had an uneventful postoperative course but continues to be somewhat confused. The lesion consisted of a remarkable chronic inflammatory cell infiltrate permeating the pineal lobules and was composed of T and B lymphocytes, macrophages, eosinophils, and mast cells. Immunoperoxidase studies did not demonstrate Langerhans cells, and a search for microorganisms was unrevealing. There was no evidence of neoplasia; results of immunostaining for germ cell markers and other tumor-associated antigens were negative.

KW - Idiopathic pinealitis

KW - Pineal gland

KW - Pineal inflammation

UR - http://www.scopus.com/inward/record.url?scp=0032742471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032742471&partnerID=8YFLogxK

M3 - Article

VL - 91

SP - 330

EP - 334

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - 2

ER -