TY - JOUR
T1 - Idiopathic pinealitis
T2 - Case report
AU - Nikas, Demetrios C.
AU - De Girolami, Umberto
AU - Zamani, Amir A.
AU - Pinkus, Geraldine S.
AU - Bello, Lorenzo
AU - Kirsch, Matthias
AU - Black, Peter Mc L
PY - 1999/8
Y1 - 1999/8
N2 - This 63-year-old man presented with complaints of 'having a feeling of falling backward' over a 3-month period. Results of his general physical examination, laboratory studies, and neurological examination were unremarkable. A magnetic resonance image revealed a 1.8 x 1.4 x 1.2-cm enhancing mass in the posterior third ventricle just above the corpora quadrigemina. The pineal gland was found to be diffusely enlarged at operation and separable from the posterior thalamus and was totally resected. The patient had an uneventful postoperative course but continues to be somewhat confused. The lesion consisted of a remarkable chronic inflammatory cell infiltrate permeating the pineal lobules and was composed of T and B lymphocytes, macrophages, eosinophils, and mast cells. Immunoperoxidase studies did not demonstrate Langerhans cells, and a search for microorganisms was unrevealing. There was no evidence of neoplasia; results of immunostaining for germ cell markers and other tumor-associated antigens were negative.
AB - This 63-year-old man presented with complaints of 'having a feeling of falling backward' over a 3-month period. Results of his general physical examination, laboratory studies, and neurological examination were unremarkable. A magnetic resonance image revealed a 1.8 x 1.4 x 1.2-cm enhancing mass in the posterior third ventricle just above the corpora quadrigemina. The pineal gland was found to be diffusely enlarged at operation and separable from the posterior thalamus and was totally resected. The patient had an uneventful postoperative course but continues to be somewhat confused. The lesion consisted of a remarkable chronic inflammatory cell infiltrate permeating the pineal lobules and was composed of T and B lymphocytes, macrophages, eosinophils, and mast cells. Immunoperoxidase studies did not demonstrate Langerhans cells, and a search for microorganisms was unrevealing. There was no evidence of neoplasia; results of immunostaining for germ cell markers and other tumor-associated antigens were negative.
KW - Idiopathic pinealitis
KW - Pineal gland
KW - Pineal inflammation
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M3 - Article
C2 - 10433325
AN - SCOPUS:0032742471
VL - 91
SP - 330
EP - 334
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - 2
ER -