Idiopathic recurring stupor: A case with possible involvement of the gamma-aminobutyric acid (GABA)ergic system

P. Tinuper, P. Montagna, P. Cortelli, P. Avoni, A. Lugaresi, P. Schoch, E. P. Bonetti, R. Gallassi, E. Sforza, E. Lugaresi

Research output: Contribution to journalArticle

Abstract

A patient had recurrent spontaneous episodes of stupor or coma in the absence of toxic, metabolic, or structural brain damage. Ictal electroencephalography showed fast 14 Hz background activity; sleep studies excluded narcolepsy. Flumazenil (Anexate), a benzodiazepine antagonist, promptly resolved the episodes and normalized the electroencephalogram. Radioreceptor binding studies showed the presence of a ligand to the central benzodiazepine receptor in plasma and cerebrospinal fluid during the episodes, suggesting a gamma-aminobutyric acid (GABA)ergic system involvement in the origin of the attacks.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalAnnals of Neurology
Volume31
Issue number5
Publication statusPublished - May 1992

ASJC Scopus subject areas

  • Neuroscience(all)

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    Tinuper, P., Montagna, P., Cortelli, P., Avoni, P., Lugaresi, A., Schoch, P., Bonetti, E. P., Gallassi, R., Sforza, E., & Lugaresi, E. (1992). Idiopathic recurring stupor: A case with possible involvement of the gamma-aminobutyric acid (GABA)ergic system. Annals of Neurology, 31(5), 503-506.