IDPN impairs post-traumatic regeneration of rat sciatic nerve

M. Morbin, S. Monaco, G. Zanette, N. Rizzuto

Research output: Contribution to journalArticle

Abstract

The role played by cytoskeletal proteins in nerve regeneration was investigated in a model in which the axonal transport of neurofilaments (NF) is almost selectively impaired. The administration of β, β'-iminodipropionitrile (IDPN), a synthetic lathyrogenic compound, induces an axonopathy characterized by proximal axonal enlargements, due to NF accumulation, and by diffuse atrophic changes associated with spatial segregation of NF from microtubules (MT). We investigated post-axotomy regeneration of rat sciatic nerve following IDPN administration. Changes induced by IDPN, as examined in the proximal and distal nerve stump at 15 and 30 days after lesion, consisted of a statistically significant reduction of the mean axonal diameter (P

Original languageEnglish
Pages (from-to)489-499
Number of pages11
JournalNeuropathology and Applied Neurobiology
Volume19
Issue number6
Publication statusPublished - 1993

Keywords

  • Axon reaction
  • Axonal swelling
  • Axonal transport
  • IDPN
  • Neurofilaments
  • Regeneration

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

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  • Cite this

    Morbin, M., Monaco, S., Zanette, G., & Rizzuto, N. (1993). IDPN impairs post-traumatic regeneration of rat sciatic nerve. Neuropathology and Applied Neurobiology, 19(6), 489-499.