Idrapril, a novel ACE inhibitor

Roberto Latini; Serge Masson; Giuseppina Luvarà; Gordana Jeremic; Fabio Fiordaliso

Idrapril, a novel ACE inhibitor

Roberto Latini, Serge Masson, Giuseppina Luvarà, Gordana Jeremic, Fabio Fiordaliso

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Idrapril, the prototype of a new clinical class of ACE inhibitors, has a pharmacological profile similar to captopril in animals. Preliminary experimental data suggest a lower potential for inducing cough compared to captopril. In humans, it has a short elimination half-life of about 2 h, but a much longer effect on RAS and blood pressure (12 to 24 h), without affecting heart rate.

Original language	English
Pages (from-to)	351-363
Number of pages	13
Journal	Cardiovascular Drug Reviews
Volume	14
Issue number	4
Publication status	Published - 1996

Keywords

Angiotensin-converting enzyme inhibitor
Antihypertensives
Heart
Idrapril

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine

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abstract = "Idrapril, the prototype of a new clinical class of ACE inhibitors, has a pharmacological profile similar to captopril in animals. Preliminary experimental data suggest a lower potential for inducing cough compared to captopril. In humans, it has a short elimination half-life of about 2 h, but a much longer effect on RAS and blood pressure (12 to 24 h), without affecting heart rate.",

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