IFN-γ low production capacity in type 1 diabetes mellitus patients at onset of disease

Maria A. Avanzini, L. Ciardelli, E. Lenta, A. M. Castellazzi, M. Marconi, G. Derosa, C. Dos Santos, M. Oliveri, A. Pistorio, R. Lorini, G. D'Annunzio

Research output: Contribution to journalArticlepeer-review

Abstract

In type 1 diabetes mellitus (T1DM), cytokines can be directly cytotoxic to β-cells, and/or play an indirect role influencing some cells of the immune system. Since several factors could impair cytokine serum levels, the purpose of our study was to longitudi-nally evaluate intracellular cytokines, in T1DM patients, and in subject at risk, by flow cytometry analysis. At T1DM onset we observed significantly lower percentage of peripheral CD4+ and CD8+ cells producing IFN-γ in patients compared to controls and subjects at risk. The 15-month follow-up patients showed significantly lower percentage of CD4+ and CD8+ cells producing IFN-γ compared to the other groups. At 8-year follow-up no significant differences were observed among the groups in the percentage of cells producing cytokines. We could have considered "exhausted cells" or these T cell subsets may be migrated from peripheral blood to pancreas. On the other hand, our results are in agreement with those reported in literature: in animal model the absence of IFN-γ production makes β-cells highly susceptible to viral infection and subsequent attack by natural killer cells, which lead to hyperglycaemia and diabetes mellitus.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalExperimental and Clinical Endocrinology and Diabetes
Volume113
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • CD4+
  • CD8+
  • Cytokines
  • IFN-γ
  • T1DM

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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