Ifosfamide and vinorelbine: An active regimen for patients with relapsed or refractory Hodgkin's disease

V. Bonfante; S. Viviani; A. Santoro; L. Devizzi; A. Di Russo; M. Zanini; F. Soncini; H. Soto Parra; P. Valagussa; G. Bonadonna

doi:10.1046/j.1365-2141.1998.00989.x

Ifosfamide and vinorelbine: An active regimen for patients with relapsed or refractory Hodgkin's disease

V. Bonfante, S. Viviani, A. Santoro, L. Devizzi, A. Di Russo, M. Zanini, F. Soncini, H. Soto Parra, P. Valagussa, G. Bonadonna

Research output: Contribution to journal › Article › peer-review

Abstract

Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m²/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m², i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.

Original language	English
Pages (from-to)	533-535
Number of pages	3
Journal	British Journal of Haematology
Volume	103
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2141.1998.00989.x
Publication status	Published - 1998

Keywords

Hodgkin's disease
Ifosfamide
Recurrent disease
Salvage therapy
Vinorelbine

ASJC Scopus subject areas

Hematology

Access to Document

10.1046/j.1365-2141.1998.00989.x

Cite this

Ifosfamide and vinorelbine : An active regimen for patients with relapsed or refractory Hodgkin's disease. / Bonfante, V.; Viviani, S.; Santoro, A.; Devizzi, L.; Di Russo, A.; Zanini, M.; Soncini, F.; Parra, H. Soto; Valagussa, P.; Bonadonna, G.

In: British Journal of Haematology, Vol. 103, No. 2, 1998, p. 533-535.

Research output: Contribution to journal › Article › peer-review

@article{c767d2695d7540e29400436996f11002,

title = "Ifosfamide and vinorelbine: An active regimen for patients with relapsed or refractory Hodgkin's disease",

abstract = "Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.",

keywords = "Hodgkin's disease, Ifosfamide, Recurrent disease, Salvage therapy, Vinorelbine",

author = "V. Bonfante and S. Viviani and A. Santoro and L. Devizzi and {Di Russo}, A. and M. Zanini and F. Soncini and Parra, {H. Soto} and P. Valagussa and G. Bonadonna",

year = "1998",

doi = "10.1046/j.1365-2141.1998.00989.x",

language = "English",

volume = "103",

pages = "533--535",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley & Sons, Ltd (10.1111)",

number = "2",

}

TY - JOUR

T1 - Ifosfamide and vinorelbine

T2 - An active regimen for patients with relapsed or refractory Hodgkin's disease

AU - Bonfante, V.

AU - Viviani, S.

AU - Santoro, A.

AU - Devizzi, L.

AU - Di Russo, A.

AU - Zanini, M.

AU - Soncini, F.

AU - Parra, H. Soto

AU - Valagussa, P.

AU - Bonadonna, G.

PY - 1998

Y1 - 1998

N2 - Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.

AB - Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.

KW - Hodgkin's disease

KW - Ifosfamide

KW - Recurrent disease

KW - Salvage therapy

KW - Vinorelbine

UR - http://www.scopus.com/inward/record.url?scp=7844249784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7844249784&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.1998.00989.x

DO - 10.1046/j.1365-2141.1998.00989.x

M3 - Article

C2 - 9827930

AN - SCOPUS:7844249784

VL - 103

SP - 533

EP - 535

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 2

ER -

Ifosfamide and vinorelbine: An active regimen for patients with relapsed or refractory Hodgkin's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this