Abstract
Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.
| Original language | English |
|---|---|
| Pages (from-to) | 533-535 |
| Number of pages | 3 |
| Journal | British Journal of Haematology |
| Volume | 103 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1998 |
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Keywords
- Hodgkin's disease
- Ifosfamide
- Recurrent disease
- Salvage therapy
- Vinorelbine
ASJC Scopus subject areas
- Hematology
Cite this
Ifosfamide and vinorelbine : An active regimen for patients with relapsed or refractory Hodgkin's disease. / Bonfante, V.; Viviani, S.; Santoro, A.; Devizzi, L.; Di Russo, A.; Zanini, M.; Soncini, F.; Parra, H. Soto; Valagussa, P.; Bonadonna, G.
In: British Journal of Haematology, Vol. 103, No. 2, 1998, p. 533-535.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ifosfamide and vinorelbine
T2 - An active regimen for patients with relapsed or refractory Hodgkin's disease
AU - Bonfante, V.
AU - Viviani, S.
AU - Santoro, A.
AU - Devizzi, L.
AU - Di Russo, A.
AU - Zanini, M.
AU - Soncini, F.
AU - Parra, H. Soto
AU - Valagussa, P.
AU - Bonadonna, G.
PY - 1998
Y1 - 1998
N2 - Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.
AB - Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.
KW - Hodgkin's disease
KW - Ifosfamide
KW - Recurrent disease
KW - Salvage therapy
KW - Vinorelbine
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UR - http://www.scopus.com/inward/citedby.url?scp=7844249784&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.1998.00989.x
DO - 10.1046/j.1365-2141.1998.00989.x
M3 - Article
C2 - 9827930
AN - SCOPUS:7844249784
VL - 103
SP - 533
EP - 535
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 2
ER -