Ifosfamide and vinorelbine: An active regimen for patients with relapsed or refractory Hodgkin's disease

V. Bonfante, S. Viviani, A. Santoro, L. Devizzi, A. Di Russo, M. Zanini, F. Soncini, H. Soto Parra, P. Valagussa, G. Bonadonna

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalBritish Journal of Haematology
Volume103
Issue number2
DOIs
Publication statusPublished - 1998

Keywords

  • Hodgkin's disease
  • Ifosfamide
  • Recurrent disease
  • Salvage therapy
  • Vinorelbine

ASJC Scopus subject areas

  • Hematology

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