Ifosfamide and vinorelbine: An active regimen for patients with relapsed or refractory Hodgkin's disease

V. Bonfante; S. Viviani; A. Santoro; L. Devizzi; A. Di Russo; M. Zanini; F. Soncini; H. Soto Parra; P. Valagussa; G. Bonadonna

doi:10.1046/j.1365-2141.1998.00989.x

Ifosfamide and vinorelbine: An active regimen for patients with relapsed or refractory Hodgkin's disease

V. Bonfante, S. Viviani, A. Santoro, L. Devizzi, A. Di Russo, M. Zanini, F. Soncini, H. Soto Parra, P. Valagussa, G. Bonadonna

Research output: Contribution to journal › Article › peer-review

Abstract

Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m²/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m², i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.

Original language	English
Pages (from-to)	533-535
Number of pages	3
Journal	British Journal of Haematology
Volume	103
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2141.1998.00989.x
Publication status	Published - 1998

Keywords

Hodgkin's disease
Ifosfamide
Recurrent disease
Salvage therapy
Vinorelbine

ASJC Scopus subject areas

Hematology

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Ifosfamide and vinorelbine : An active regimen for patients with relapsed or refractory Hodgkin's disease. / Bonfante, V.; Viviani, S.; Santoro, A.; Devizzi, L.; Di Russo, A.; Zanini, M.; Soncini, F.; Parra, H. Soto; Valagussa, P.; Bonadonna, G.

In: British Journal of Haematology, Vol. 103, No. 2, 1998, p. 533-535.

Research output: Contribution to journal › Article › peer-review

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AU - Zanini, M.

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