Ifosfamide and vinorelbine in advanced pretreated ovarian cancer: A phase II study

Mario Nardi, Salvatore De Marco, Alessandra Fabi, Alessandra Aloe, Elena Magnani, Pierpaolo Grandinetti, Francesco Cognetti

Research output: Contribution to journalArticle

Abstract

Purpose: The response rate to salvage chemotherapy in advanced ovarian cancer (AOC) has been disappointing in patients who do not respond or relapse after platinum-containing regimens. Ifosfamide (IFO) showed an overall response rate of 20% and vinorelbine (VNR) 15.6%. Trials of the association of these two drugs for AOC have not yet been published. Patients and methods: Between April 1996 and August 1997, 17 patients with AOC were treated with intravenous IFO 2000 mg/m2 per day, days 1 to 3, with mesna uroprotection, and VNR 25 mg/m2 per day, days 1 and 8, every 3 weeks. All patients but one had been heavily pretreated. All patients had been treated with platinum compounds and 16/17 with taxanes. Results: All 17 patients were evaluable for toxicity, and 16 for response (one lost to follow-up). One patient showed a partial response, 12 progressive disease and three stable disease. No complete responses were observed. The main toxicity was neutropenia (grade 3- 4 in 82% of patients) with neutropenic fever in 17.6% of patients. In 70.5% of patients (19/59 of courses) VNR was not administered on day 8. In four patients (10/59 courses) the dose was reduced by 25% for persistent leukopenia grade 2-3. Other toxicities were not significant. Conclusions: This combination showed no activity in this set of patients. The poor outcome, as compared with the significant activity reported with the agents used singly, could be ascribed to the patients' characteristics, the low dose intensity of VNR administered and possible cross-resistance between the study drugs and previously used agents.

Original languageEnglish
Pages (from-to)513-515
Number of pages3
JournalCancer Chemotherapy and Pharmacology
Volume45
Issue number6
Publication statusPublished - 2000

Keywords

  • Ifosfamide
  • Ovarian cancer
  • Salvage chemotherapy
  • Vinorelbine

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology
  • Oncology

Fingerprint Dive into the research topics of 'Ifosfamide and vinorelbine in advanced pretreated ovarian cancer: A phase II study'. Together they form a unique fingerprint.

Cite this