Ifosfamide in the elderly: Clinical considerations for a better drug management

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The therapeutic strategy used for elderly affected by malignant neoplasms should take into account the common variables present in oncological patients, and the specific alteration of the elderly metabolism and their possible morbidity. Ifosfamide is an active drug for various tumors with elevated incidence in the elderly. We analyze the principle criteria in the selection of these patients and the alterations of metabolism which correlates to aging with their consequences on the pharmacokinetics of ifosfamide. Finally, we propose clinical guidelines to optimize the use of ifosfamide in elderly patients affected by malignant tumors. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalCritical Reviews in Oncology/Hematology
Issue number2
Publication statusPublished - Feb 2000


  • Clinical considerations
  • Elderly
  • Ifosfamide

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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