IgA antigliadin antibodies, cellobiose/mannitol sugar test, and carotenemia in the diagnosis of and screening for celiac disease

M. T. Bardella, N. Molteni, B. Cesana, A. R. Baldassarri, P. A. Bianchi

Research output: Contribution to journalArticle

Abstract

Serum IgA antigliadin antibodies (IgAAGA) assay, cellobiose/mannitol sugar permeability test (ST), and carotenemia were evaluated prospectively as diagnostic tests in 60 consecutive adult patients with suspected celiac disease (CD). CD was confirmed histologically in 26 patients. IgAAGA, ST, and carotenemia had a sensitivity of 65.4%, 96.2%, and 76.9%, a specificity of 97.1%, 73.5%, and 70.6%, and positive likelihood ratio of 22.2, 3.6, and 2.6, respectively. Multivariate logistic regression showed that IgAAGA and ST had a sensitivity and specificity of 96.2% and 70.6% and a positive likelihood ratio of 47.3 if both were positive. Assuming a prevalence of CD of 1:2000 in the general population, for every 89 positive IgAAGA and 549 altered ST there would be one celiac patient, whereas, if both tests were positive, the patient was certain to have CD. We conclude that, of the tests studied, IgAAGA and ST are respectively the most specific and the most sensitive and that, used together, they can diagnose CD.

Original languageEnglish
Pages (from-to)309-311
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume86
Issue number3
Publication statusPublished - 1991

Fingerprint

Cellobiose
Celiac Disease
Mannitol
Immunoglobulin A
Permeability
Antibodies
Routine Diagnostic Tests
Abdomen
Logistic Models
Sensitivity and Specificity
Serum
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

IgA antigliadin antibodies, cellobiose/mannitol sugar test, and carotenemia in the diagnosis of and screening for celiac disease. / Bardella, M. T.; Molteni, N.; Cesana, B.; Baldassarri, A. R.; Bianchi, P. A.

In: American Journal of Gastroenterology, Vol. 86, No. 3, 1991, p. 309-311.

Research output: Contribution to journalArticle

Bardella, M. T. ; Molteni, N. ; Cesana, B. ; Baldassarri, A. R. ; Bianchi, P. A. / IgA antigliadin antibodies, cellobiose/mannitol sugar test, and carotenemia in the diagnosis of and screening for celiac disease. In: American Journal of Gastroenterology. 1991 ; Vol. 86, No. 3. pp. 309-311.
@article{114f26e9748b496c8bbb9008cbd343e8,
title = "IgA antigliadin antibodies, cellobiose/mannitol sugar test, and carotenemia in the diagnosis of and screening for celiac disease",
abstract = "Serum IgA antigliadin antibodies (IgAAGA) assay, cellobiose/mannitol sugar permeability test (ST), and carotenemia were evaluated prospectively as diagnostic tests in 60 consecutive adult patients with suspected celiac disease (CD). CD was confirmed histologically in 26 patients. IgAAGA, ST, and carotenemia had a sensitivity of 65.4{\%}, 96.2{\%}, and 76.9{\%}, a specificity of 97.1{\%}, 73.5{\%}, and 70.6{\%}, and positive likelihood ratio of 22.2, 3.6, and 2.6, respectively. Multivariate logistic regression showed that IgAAGA and ST had a sensitivity and specificity of 96.2{\%} and 70.6{\%} and a positive likelihood ratio of 47.3 if both were positive. Assuming a prevalence of CD of 1:2000 in the general population, for every 89 positive IgAAGA and 549 altered ST there would be one celiac patient, whereas, if both tests were positive, the patient was certain to have CD. We conclude that, of the tests studied, IgAAGA and ST are respectively the most specific and the most sensitive and that, used together, they can diagnose CD.",
author = "Bardella, {M. T.} and N. Molteni and B. Cesana and Baldassarri, {A. R.} and Bianchi, {P. A.}",
year = "1991",
language = "English",
volume = "86",
pages = "309--311",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - IgA antigliadin antibodies, cellobiose/mannitol sugar test, and carotenemia in the diagnosis of and screening for celiac disease

AU - Bardella, M. T.

AU - Molteni, N.

AU - Cesana, B.

AU - Baldassarri, A. R.

AU - Bianchi, P. A.

PY - 1991

Y1 - 1991

N2 - Serum IgA antigliadin antibodies (IgAAGA) assay, cellobiose/mannitol sugar permeability test (ST), and carotenemia were evaluated prospectively as diagnostic tests in 60 consecutive adult patients with suspected celiac disease (CD). CD was confirmed histologically in 26 patients. IgAAGA, ST, and carotenemia had a sensitivity of 65.4%, 96.2%, and 76.9%, a specificity of 97.1%, 73.5%, and 70.6%, and positive likelihood ratio of 22.2, 3.6, and 2.6, respectively. Multivariate logistic regression showed that IgAAGA and ST had a sensitivity and specificity of 96.2% and 70.6% and a positive likelihood ratio of 47.3 if both were positive. Assuming a prevalence of CD of 1:2000 in the general population, for every 89 positive IgAAGA and 549 altered ST there would be one celiac patient, whereas, if both tests were positive, the patient was certain to have CD. We conclude that, of the tests studied, IgAAGA and ST are respectively the most specific and the most sensitive and that, used together, they can diagnose CD.

AB - Serum IgA antigliadin antibodies (IgAAGA) assay, cellobiose/mannitol sugar permeability test (ST), and carotenemia were evaluated prospectively as diagnostic tests in 60 consecutive adult patients with suspected celiac disease (CD). CD was confirmed histologically in 26 patients. IgAAGA, ST, and carotenemia had a sensitivity of 65.4%, 96.2%, and 76.9%, a specificity of 97.1%, 73.5%, and 70.6%, and positive likelihood ratio of 22.2, 3.6, and 2.6, respectively. Multivariate logistic regression showed that IgAAGA and ST had a sensitivity and specificity of 96.2% and 70.6% and a positive likelihood ratio of 47.3 if both were positive. Assuming a prevalence of CD of 1:2000 in the general population, for every 89 positive IgAAGA and 549 altered ST there would be one celiac patient, whereas, if both tests were positive, the patient was certain to have CD. We conclude that, of the tests studied, IgAAGA and ST are respectively the most specific and the most sensitive and that, used together, they can diagnose CD.

UR - http://www.scopus.com/inward/record.url?scp=0025735962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025735962&partnerID=8YFLogxK

M3 - Article

C2 - 1900142

AN - SCOPUS:0025735962

VL - 86

SP - 309

EP - 311

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 3

ER -