IgA-containing plasma cells in the intestinal mucosa of children with selective IgA deficiency

M. S. Scotta; G. Maggiore; C. de Giacomo; A. Martini; V. L. Burgio; A. G. Ugazio

IgA-containing plasma cells in the intestinal mucosa of children with selective IgA deficiency

M. S. Scotta, G. Maggiore, C. de Giacomo, A. Martini, V. L. Burgio, A. G. Ugazio

Research output: Contribution to journal › Article › peer-review

Abstract

In 8 children with selective IgA deficiency (serum IgA <5 mg/dl, secretory IgA <0.5 mg/dl in unstimulated saliva) immunofluorescent staining of intestinal biopsy specimens revealed the presence of IgA-containing plasma cells. This finding supports the hypothesis that in the intestinal mucosa of patients with IgA deficiency B lymphocytes undergo 'sterile' differentiation into IgA-containing plasma cells probably incapable of secreting the IgA synthesized.

Original language	English
Pages (from-to)	173-175
Number of pages	3
Journal	Journal of Clinical and Laboratory Immunology
Volume	9
Issue number	3
Publication status	Published - 1982

ASJC Scopus subject areas

Immunology

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title = "IgA-containing plasma cells in the intestinal mucosa of children with selective IgA deficiency",

abstract = "In 8 children with selective IgA deficiency (serum IgA <5 mg/dl, secretory IgA <0.5 mg/dl in unstimulated saliva) immunofluorescent staining of intestinal biopsy specimens revealed the presence of IgA-containing plasma cells. This finding supports the hypothesis that in the intestinal mucosa of patients with IgA deficiency B lymphocytes undergo 'sterile' differentiation into IgA-containing plasma cells probably incapable of secreting the IgA synthesized.",

author = "Scotta, {M. S.} and G. Maggiore and {de Giacomo}, C. and A. Martini and Burgio, {V. L.} and Ugazio, {A. G.}",

year = "1982",

language = "English",

volume = "9",

pages = "173--175",

journal = "Journal of Clinical and Laboratory Immunology",

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T1 - IgA-containing plasma cells in the intestinal mucosa of children with selective IgA deficiency

AU - Scotta, M. S.

AU - Maggiore, G.

AU - de Giacomo, C.

AU - Martini, A.

AU - Burgio, V. L.

AU - Ugazio, A. G.

PY - 1982

Y1 - 1982

N2 - In 8 children with selective IgA deficiency (serum IgA <5 mg/dl, secretory IgA <0.5 mg/dl in unstimulated saliva) immunofluorescent staining of intestinal biopsy specimens revealed the presence of IgA-containing plasma cells. This finding supports the hypothesis that in the intestinal mucosa of patients with IgA deficiency B lymphocytes undergo 'sterile' differentiation into IgA-containing plasma cells probably incapable of secreting the IgA synthesized.

AB - In 8 children with selective IgA deficiency (serum IgA <5 mg/dl, secretory IgA <0.5 mg/dl in unstimulated saliva) immunofluorescent staining of intestinal biopsy specimens revealed the presence of IgA-containing plasma cells. This finding supports the hypothesis that in the intestinal mucosa of patients with IgA deficiency B lymphocytes undergo 'sterile' differentiation into IgA-containing plasma cells probably incapable of secreting the IgA synthesized.

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