IgA-containing plasma cells in the intestinal mucosa of children with selective IgA deficiency

M. S. Scotta, G. Maggiore, C. de Giacomo, A. Martini, V. L. Burgio, A. G. Ugazio

Research output: Contribution to journalArticlepeer-review

Abstract

In 8 children with selective IgA deficiency (serum IgA <5 mg/dl, secretory IgA <0.5 mg/dl in unstimulated saliva) immunofluorescent staining of intestinal biopsy specimens revealed the presence of IgA-containing plasma cells. This finding supports the hypothesis that in the intestinal mucosa of patients with IgA deficiency B lymphocytes undergo 'sterile' differentiation into IgA-containing plasma cells probably incapable of secreting the IgA synthesized.

Original languageEnglish
Pages (from-to)173-175
Number of pages3
JournalJournal of Clinical and Laboratory Immunology
Volume9
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Immunology

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