In 8 children with selective IgA deficiency (serum IgA <5 mg/dl, secretory IgA <0.5 mg/dl in unstimulated saliva) immunofluorescent staining of intestinal biopsy specimens revealed the presence of IgA-containing plasma cells. This finding supports the hypothesis that in the intestinal mucosa of patients with IgA deficiency B lymphocytes undergo 'sterile' differentiation into IgA-containing plasma cells probably incapable of secreting the IgA synthesized.
|Number of pages||3|
|Journal||Journal of Clinical and Laboratory Immunology|
|Publication status||Published - 1982|
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