IgE in childhood asthma: Relevance of demographic characteristics and polysensitisation

M. Silvestri, A. Pistorio, E. Battistini, Giovanni A. Rossi

Research output: Contribution to journalArticle

Abstract

Background: Despite the therapeutic efficacy of the anti-IgE monoclonal antibody, the role of IgE in allergic asthma is still a matter of debate. This may be mostly relevant in childhood, where a wide range of total serum (s) IgE levels is often detected. Aim: To evaluate whether the relationships between total or allergen-specific sIgE levels and the clinical markers of allergic inflammation and the pulmonary function values might be affected by the demographic characteristics of the patients or by the presence of multiple sensitisations to allergens. Methods: 64 asthmatic children sensitised to house dust mites (HDM) were evaluated. The role of age, sex and multiple sensitisations was evaluated by multiple regression model (MRM) analysis. Results: Total and HDM-specific sIgE levels (Log) showed similar moderate-to-strong correlations with exhaled nitric oxide (FENO) and blood eosinophilia (Log) (p1), %FEV 1 change after salbutamol. The positive associations between total sIgE levels and Log FENO levels or Log blood eosinophilia were also detected by MRM analysis. Age brought a negative, although limited, contribution to FENO levels and blood eosinophilia (p

Original languageEnglish
Pages (from-to)979-984
Number of pages6
JournalArchives of Disease in Childhood
Volume95
Issue number12
DOIs
Publication statusPublished - Dec 2010

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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